大庆地区2013年-2015年金黄色葡萄球菌耐药性分析  

Surveillance on drug resistance of Staphylococcus aureus in Daqing area from 2013 to 2015

作　　者：付宝庆[1] 齐文晶 胡春岭[1] 李杨[2] 姜洪文[1] 常纪[1] FU Bao -qing QI Wen -jing HU Chun -ling LI Yang JIANG Hong- wen CHANG Ji(Clinical Laboratory, General Hospital ofDaqing Oilfield, Daqing, Heilongjiang 163001, China)

机构地区：[1]大庆油田总医院检验科,黑龙江大庆163001 [2]大庆油田总医院感染科,黑龙江大庆163001

出　　处：《中国卫生检验杂志》2017年第5期748-750,753,共4页Chinese Journal of Health Laboratory Technology

摘　　要：目的了解大庆油田总医院2013年-2015年金黄色葡萄球菌的临床分布和耐药性变迁,为临床合理使用抗菌药物提供依据。方法采用VITEK 2全自动微生物鉴定药敏系统对金黄色葡萄球菌进行检测,根据CLSI 2015年标准判定结果,使用WHONET 5.6进行数据分析。结果 3年共检出金黄色葡萄球菌3 039株,其中耐甲氧西林金黄色葡萄球菌(MRSA)939株(30.9%),MRSA检出率呈上升趋势。痰液、分泌物和咽拭子为主要标本来源,神经外科、耳鼻喉科、ICU及儿科病房为金黄色葡萄球菌的主要检出病区。本地区金黄色葡萄球菌对青霉素、红霉素耐药率较高,在70%以上;利福平和呋喃妥因较敏感,敏感率在80%以上;未发现万古霉素、利奈唑胺、奎奴普汀/达福普汀及替加环素耐药的菌株。结论本地区3年间金黄色葡萄球菌对临床常用抗菌药物的耐药率保持在较低的水平,但MRSA检出率有逐年上升的趋势,临床应合理使用抗菌药物。Objective To investigate the clinical distribution and drug resistance of Staphylococcus aureus from January 2013 to December 2015 in Daqing Oilfield General Hospital,so as to provide evidence for the rational use of antibiotics.Methods Staphylococcus aureus was detected by VITEK 2 system,and the results of antimicrobial susceptibility were determined according to CLSI2015 criteria.All data were analyzed by WHONET 5.6.Results 3 039 strains of Staphylococcus aureus（ S.a） were isolated in3 years,including 939 strains of methicillin-resistant Staphylococcus aureus（ MRSA）,and the detection rate was 30.9%.The detection rate of MRSA showed an ascending trend.Sputum,secretions and throat swabs were the main sources of specimen,and neurosurgery,otolaryngology,ICU and pediatric wards were the main detection wards.The resistance rates of S.a to penicillin and erythromycin were higher than 70%.The sensitiveness rates of S.a to rifampicin and nitrofurantoin were more than80%.Vancomycin,linezolid,quinupristin/dalfopristin,and tigecycline-resistant strains were not found.Conclusion The resistant rate of S.a to the commonly used drugs in the three years kept low,but the detection rate of MRSA was increasing year by year.Antimicrobial agents should be rationally used in clinic.

关 键 词：金黄色葡萄球菌 耐甲氧西林金黄色葡萄球菌 耐药性 

分 类 号：R446.5[医药卫生—诊断学]