赤峰地区丙肝基因分型及其临床意义分析  

The Classification and Clinical Significance of Hepatitis C Gene in Chifeng Area

作　　者：尚明全[1] 李连友[1] 李连兴[2] 

机构地区：[1]赤峰市医院检验科,内蒙古赤峰024000 [2]赤峰市医院科教科,内蒙古赤峰024000

出　　处：《中国卫生标准管理》2017年第5期2-4,共3页China Health Standard Management

摘　　要：目的探讨赤峰地区丙肝基因分型及其临床意义。方法选取2012年1月—2016年12月赤峰地区796例HCV患者作为研究对象,分析基因型与HCVRNA含量、AST含量、ALT含量的相关性。结果 HBV、HCV重叠感染者中混合基因型高于单纯HCV感染,χ2=32.24,P<0.01。1型(1a+1b)基因型HCV感染患者血清HCVRNA病毒载量、AST、ALT水平均高于2型(2a)、3型(3a+3b)、6型(6a)基因型HCV感染者,均P<0.05。结论赤峰地区HCV基因型呈现多样化散在分布,其中以1b型基因型为主,HCV基因型与病毒载量、肝脏损伤程度密切相关。Objective To investigate the gene of hepatitis C in Chifeng area and its clinical significance. Methods From January 2012 to December 2016, 796 patients with HCV in Chifeng area were selected as the research object, and the correlation between genotype and HCVRNA content, AST content and ALT content was analyzed. Results In HBV and HCV superinfection, the mixed genotype was significantly higher than that of simple HCV infection, χ^2=32.24, P 〈 0.01. The serum HCVRNA viral load, AST and ALT levels in patients with type 1 （1a＋1b） genotype HCV infection were significantly higher than those of type 2 （2a）, type 3 （3a＋3b）, type 6 （6a） genotype HCV infection, all of which were P 〈 0.05. Conclusion The HCV genotypes in Chifeng area are distributed in a variety of ways, including lb genotype, HCV genotype is closely related to viral load and liver injury.

关 键 词：基因分型 丙型肝炎病毒 赤峰地区 

分 类 号：R512.33[医药卫生—内科学]