细菌天然群体感应信号分子抑制剂研究进展  

Study on Natural Quorum Sensing Inhibitor of Bacteria

作　　者：马艳平[1] 梁志凌[1] 马江耀[1] 郝乐[1] 柯浩[1] 刘振兴[1] 

机构地区：[1]广东省农业科学院动物卫生研究所广东省畜禽疫病防治研究重点实验室广东省兽医公共卫生公共实验室,广东广州510640

出　　处：《广东畜牧兽医科技》2017年第1期1-5,共5页Guangdong Journal of Animal and Veterinary Science

基　　金：广东省海洋渔业局科技与产业发展专项(A201401C06);广州市科技攻关(2014J4100229)

摘　　要：长期抗生素滥用导致了多重耐药菌株及其超级细菌的出现,由密度感应系统调控的生物被膜的形成和成熟是造成细菌感染的机制之一。自然界存在的生物活性物质能够淬灭密度感应系统,这些生物活性物质被称为群体感应信号分子抑制剂(quorum sensing inhibitor,QSI)。近年来,群体感应抑制剂成为细菌抗感染药物开发的靶点,有必要对细菌群体感应信号分子抑制剂种类、作用机制进行研究,本文综述了细菌天然群体感应信号分子抑制剂,干扰群体感应系统,从而治疗细菌感染。绝大多数原核生物能够产生群体感应抑制剂,这被认为是安全的。动物、豆类、传统的药用植物、海洋生物均能产生群体感应抑制剂。这些天然抑制剂可能替代传统抗生素,具有广阔的研究和应用前景。Excessive and indiscriminate use of antibiotics to treat bacterial infections has led to the emergence of multiple drug resistant strains and super bacteria. Most infectious diseases are caused by bacteria which proliferate within quorum sensing（QS） mediated biofilms. These molecules act primarily by quenching the QS system. The molecule is also termed as quorum sensing inhibitor（QSI）. In recent years, the quorum sensing inhibitors become the target of the development of bacterial resistance to infection drugs, it is necessary to study bacterial quorum sensing signal molecule inhibitors types and mechanism. This review focuses detailedly on natural QSIs with the potential for treating bacterial infections. It has been opined that the most versatile prokaryotes to produce QSI are likely to be those, which are generally regarded as safe. Among the eukaryotes, certain legumes and traditional medicinal plants are likely to act as QSIs. Such findings are likely to lead to efficient treatments with much lower doses of drugs especially antibiotics than required at present.

关 键 词：群体感应系统 细菌群体感应信号分子抑制剂 种类 机理 

分 类 号：S855.1[农业科学—临床兽医学]