超氧化物歧化酶及游离脂肪酸检测在胰岛素抵抗疾病中的应用  

Clinical Application of Detection of Superoxide Dismutase and Free Fatty Acids in Patients with Insulin Resistance

作　　者：王依屹[1] 张珏[1] 鲁传翠[1] 孟佳丽[1] WANG Yi- yi ZHANG Jue LU Chuan- cui MENG Jia- li(Department of Clinical Laboratory, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China)

机构地区：[1]上海中医药大学附属曙光医院检验科,上海201203

出　　处：《标记免疫分析与临床》2017年第3期247-249,289,共4页Labeled Immunoassays and Clinical Medicine

基　　金：国家高技术研究发展计划(863计划)课题资助(课题编号:2014AA022304)

摘　　要：目的探讨超氧化物歧化酶(SOD)及游离脂肪酸(FFA)检测在胰岛素抵抗疾病中的应用价值。方法选择300例2型糖尿病(DM2)患者,其中150例合并非酒精性脂肪肝(NAFLD),空腹采血检测超氧化物歧化酶(SOD)、游离脂肪酸(FFA)、胰岛素(INS)、葡萄糖(FPG)、脂类等实验室指标,同时做肝脏瞬时弹性检查(FibroScan)和受控衰减参数(CAP);选择150例体检健康者为对照组,做相同检测。结果糖尿病组和合并NAFLD组检测结果进行对比,各项指标的差异均具有统计学意义(P<0.05),糖尿病组、合并NAFLD组与对照组的检测结果进行对比,各项指标的差异均具有统计学意义(P<0.05)。结论超氧化物歧化酶及游离脂肪酸检测在胰岛素抵抗疾病中有重要的应用价值。Objective To investigate the value of joint detection of superoxide dismutase （SOD） and free fatty acids（FFA） in insulin resistance （IR）. Methods 300 patients with type 2 diabetes mellitus （DM2）, 150 of non- alcoholic fatty liver disease （ NAFLD ） were measured for their SOD, FFA, INS, FPG, blood-lipids and FibroScan-CAP levels. Also 100 healthy cases were selected as the control group with the same tests to observe the change of myocardial markers. Results There is a significant difference （ P 〈 0.05 ） between the tests of DM2 with NAFLD group and the group without NAFLD. There is also a significant difference between（P 〈 0.05） DM2 group and the control group. Conclusion The joint detection of SOD, FFA of Insulin Resistance（IR） has the significant clinical value.

关 键 词：超氧化物歧化酶(SOD) 游离脂肪酸(FFA) 胰岛素抵抗(IR) 2型糖尿病(DM2) 非酒精性脂肪肝(NAFLD) 

分 类 号：R587.1[医药卫生—内分泌]