PM2.5与变应性鼻炎  

The relationship between PM2.5 and allergic rhinitis

作　　者：章如新[1] 郭志强[1] 

机构地区：[1]复旦大学附属华东医院耳鼻咽喉头颈外科,上海200040

出　　处：《中国耳鼻咽喉颅底外科杂志》2017年第1期1-4,共4页Chinese Journal of Otorhinolaryngology-skull Base Surgery

基　　金：国家自然科学基金项目(81371078)

摘　　要：变应性鼻炎(allergic rhinitis,AR)是一种多基因调控并与环境因素密切相关的鼻部变态反应性疾病。PM2.5被公认为大气环境中严重危害健康的污染物。鼻腔作为呼吸道防御的第一道门户,首先接触空气中的PM2.5,进而发生吸附、吸收反应,在变应性鼻炎发病中可能发挥重要角色。PM2.5对变应性鼻炎流行病学影响已受到密切关注,PM2.5与变应性鼻炎相关性及作用机制已有探索性研究。PM2.5可引起氧化损伤鼻黏膜细胞屏障功能,通过基因甲基化参与变应性鼻炎的发病。深入研究PM2.5在变应性鼻炎发病中的作用,可为变应性鼻炎的防治提供新思路。Allergic rhinitis （AR） is an allergic nasal disease, due to multiple gene regulation and more closely related to environmental factors. PM2. 5 is recognized as a health hazard of serious pollutants in the atmospheric environment. Nasal cavity, which is the first portal of respiratory defense, exposes firstly to PM2.5, and adsorbs PM2.5 to aggregative response. PM2.5 may play an important role in the pathogenesis of allergic rhinitis. PM2.5 attracts more and more attention these years due to its important roles in the epidemiological effect of AR. Exploratory studies of mechanism between PM2.5 and AR had been performed. Exposure to PM2.5 induced the oxidative stress reaction and expression of inflammatory cytokines, which contribute to the impairment of nasal epithelial barrier function. Gene methylation regulation may play essential roles on the relationship between PM2.5 and AR. To further study the effect of PM2.5 on AR can provide a new perspective of comprehensive prevention and control strategy of AR.

关 键 词：变应性鼻炎 PM2.5 发病机制 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]