稳定型与不稳定型心绞痛患者颈动脉硬化斑块新生血管超声造影特点的对比研究  

Comparative study of characteristics of carotid Artery atherosclerotic on the neovascularization of plaques in patients with stable angina and unstable angina by contrast-enhanced ultrasonography

作　　者：张凤秀[1] 潘明康[2] 陈玲丽[1] 赵君[1] 梁虹[1] 

机构地区：[1]中国科学院中关村医院超声科,100190 [2]中国科学院中关村医院心血管内科,100190

出　　处：《心肺血管病杂志》2017年第1期47-50,共4页Journal of Cardiovascular and Pulmonary Diseases

基　　金：北京市科学技术委员会基金资助项目(No.Z141100002114040)

摘　　要：目的:探讨稳定型与不稳定型心绞痛患者颈动脉粥样硬化(CAS)斑块内新生血管超声造影(CEUS)特征性改变。方法:对临床经心电图、动态心电图或平板运动试验心电图诊断的冠心病患者111例,其中稳定型心绞痛(SA)患者53例,不稳定型心绞痛(UA)患者58例,分别进行颈动脉彩色多普勒超声及CEUS检查,使用声学定量分析软件(Sono Liver)对图像进行分析,比较斑块达峰时间、最大峰值强度比、曲线下面积,分析斑块内新生血管与SA及UA的相关性,并行血清高敏C反应蛋白(hs-CRP)检测进行对比。结果:UA与SA患者CAS斑块内新生血管显像特征存在差异,UA患者CAS斑块内新生血管等级评分较SA患者中明显增高:UA组斑块内新生血管发生率明显高于SA组(P<0.05),UA组达峰时间更快、最大峰值强度比及曲线下面积更大,与SA组相比有统计学意义(P<0.05);血清hs-CRP浓度UA组也较SA组升高(P<0.05);CAS斑块内新生血管等级评分与血清hs-CRP浓度水平呈正相关。结论:CEUS技术观察CAS斑块内新生血管等级评分,为临床对UA进行早期预测及干预,以及对UA预后的判断提供重要的依据。Objective：To compare the imaging characteristics on the neovascularization in plaques of carotid Artery atherosclerotic（CAS） between patients with stable angina（SA） and unstable angina（UA） by qualitative and quantitative analysis of the plaques by contrast-enhanced uhrasonography （CEUS）. Methods： For 111 cases of the coronary heart disease patients diagnosed by ECG, Hoher or treadmill exercise test ECG, to exam with routine ultrasound and CEUS for CAS plaques in the 53 patients with SA and 58 patients with UA, and to compare with the characters of these CAS plaques. Acoustic quantitative analysis software-SonoLiver was used for offline analysis of image in neovascularization within CAS plaques ： observing the peak time, the peak intensity, the areas under the curve of various plaques, and analyzing any relevance to UA and SA. To detect and compare the level of serum hypersensitive C reactive protein （hs-CRP）. Results：There was significant differences in the properties of the neovascularization of CAS plaques in patients with UA and SA, Compared with the SA, the grade score was significantly higher of the neovascularizatiou in the plaque of CAS with UA ： The neovascularization of plaques in patients with UA group was more than that of SA group, and there was significant difference （P 〈 0. 05）, the peak time was faster, the maximum peak intensity was higher, and areas under the curve of various plaques was more in patients with UA than patients with SA, there were statistical different above from group UA and group SA（P 〈0. 05） ; The level of serum hs-CRP was higher in group UA than group SA（ P 〈0.05 ） ; The grade score of the neovascularization in the plaque of CAS was positively correlated with the level of serum hs-CRP. Conclusion：To observe the imaging characteristies of the neovaseularization in plaques of CAS by CEUS, the grade score of the nenvascularization in the plaque of CAS is an index of predictable diagnostic and prognostic evaluation for patients with

关 键 词：稳定型心绞痛 不稳定型心绞痛 超声造影 颈动脉粥样斑块 新生血管 

分 类 号：R54[医药卫生—心血管疾病]