手术干预对阻塞性睡眠呼吸暂停低通气综合征儿童外周T淋巴细胞亚群及NK细胞活性的影响  

Effect of surgical intervention on the activity of peripheral blood T lymphocyte subsets and NK cell in children with obstructive sleep apnea hypopnea syndrome

作　　者：陈翊民[1] 黄莉莉[1] 王佳蓉[1] 邱连升[1] 

机构地区：[1]福建医科大学第二临床医学院耳鼻咽喉科,福建泉州362000

出　　处：《中国耳鼻咽喉头颈外科》2017年第3期124-127,共4页Chinese Archives of Otolaryngology-Head and Neck Surgery

基　　金：福建省泉州市科技局项目(2015Z62)

摘　　要：目的研究阻塞性睡眠呼吸暂停低通气综合征(OSAHS)对患儿细胞免疫功能的影响及手术前后的变化。方法 80例OSAHS患儿,在手术前及手术后1个月对外周血T淋巴细胞亚群及NK细胞比例进行检测。同时选取80例健康儿童作为对照组。结果与对照组比较,手术前组CD4^+T细胞昕占百分比、CD4^+/CD8^+比值、NK细胞所占百分比明显减低[(26.19±3.38)%vs(5.10±4.09)%、(0.90±0.19)%vs(1.61±0.52)%、(11.45±4.35)%vs(13.73±3.78)%,P均<0.05],CD8^+T细胞昕占百分比明显升高[(30.02±5.50)%vs(22.31±3.42)%,P<0.05];手术后组CD3^+T细胞、CD4^+T细胞、CD8^+T细胞、CD4^+/CD8^+比值、NK细胞昕占百分比均与手术前组无统计学差异(P均>0.05)。结论 OSAHS可损害患儿的细胞免疫功能,而扁桃体联合腺样体手术在短期内不会导致患儿细胞免疫功能的减退.OBJECTIVE To explore the condition of the cellular immune function of children with obstructive sleep apnea hypopnea syndrome（OSAHS） and its change after operation METHODS Eighty children diagnosed as OSAHS were included in this study. T lymphocyte subsets and NK cells of the blood were measured before operation and one month after operation respectively. Children without the related disorders or systemic disease were recruited as control group.RESULTS Before operation, CD4^＋T cell percentage, CD4^＋/CD8^＋ ratio and NK cell percentage in OSAHS children were significantly lower than that in the control group[（26.19±3.38）%vs （5.10±4.09）%, （0.90±0.19）%vs （1.61±0.52）%, （11.45±4.35）%vs （13.73±3.78）%,P〈0.05], CD8^＋T cell percentage was significantly higher than that in the control group[（30.02±5.50）%vs （22.31±3.42） %,P〈0.05]. The difference, between the two groups, in CD3^＋T cells was not statistically significant. After operation, the CD4^＋T cells, CD8^＋T cells, CD4^＋/CD8^＋ ratio, the percentage of NK cells and CD3^＋T cells showed no significance difference compared with that before operation （P〉0.05）. CONCLUSION OSAHS may damage the cellular immune function. The operation does not reduce the cellular immune function in the short term.

关 键 词：睡眠呼吸暂停 阻塞性 儿童 扁桃体切除术 腺样体切除术 免疫 细胞 

分 类 号：R766.9[医药卫生—耳鼻咽喉科]