Science:研究鉴定出导致脑细胞死亡的罪魁祸首  

A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1

出　　处：《现代生物医学进展》2017年第4期I0001-I0001,共1页Progress in Modern Biomedicine

摘　　要：尽管存在不同的触发物，相同的一连串分子事件似乎导致中风、脑损伤和甚至阿尔茨海默病等神经退行性疾病中的脑细胞死亡。如今，在一项新的研究中。来自美国约翰霍普金斯大学的研究人员说，他们精确地发现一种位于这一连串事件末端的蛋白。即一种通过切割细胞的DNA给予致命性打击的蛋白。他们说，这一发现潜在地为开发预防、阻止或削弱这一过程的药物打开新的大门。相关研究结果发表在Science期刊上。Cells that experience stresses and accumulate excessive damage to DNA undergo cell death mediated by a nuclear enzyme known as PARP-1. During this process, apoptosis-inducing factor (AIF) translocates to the nucleus and activates one or more nucleases to cleave DNA. Wang et al. found that macrophage migration inhibitory factor (MIF) is an AIF-associated endonuclease that contributes to PARP-1-induced DNA fragmentation (see the Perspective by Jonas). In mouse neurons in culture, loss of MIF protected neurons from cell death caused by excessive stimulation. Targeting MIF could thus provide a therapeutic strategy against diseases in which PARP-1 activation is excessive.

关 键 词：细胞死亡 脑损伤 神经退行性疾病 鉴定 阿尔茨海默病 分子事件 研究人员 致命性 

分 类 号：Q251[生物学—细胞生物学]