川芎当归不同配伍对偏头痛大鼠体内5-HT,NO和NOS的影响研究  

Study on the Effects of Ligusticum wallichii with Different Proportion of Angelica Sinensis on the Contents of Endogenous Substances in Migraine Rats

作　　者：姜维[1] 陈曦[1] 胡娜[1] 赵美[1] 刘新友[1] 

机构地区：[1]第四军医大学唐都医院药剂科,陕西西安710038

出　　处：《现代生物医学进展》2017年第5期830-834,共5页Progress in Modern Biomedicine

基　　金：陕西省中医药管理局项目(13-ZY039)

摘　　要：目的:研究不同比例的川芎当归配伍对偏头痛大鼠体内内源性物质影响。方法:采用雄性SD大鼠,皮下注射硝酸甘油混悬液制作偏头痛大鼠模型,以偏头痛模型大鼠体内三种内源性物质5-HT、NO和NOS含量为考察指标,观察给予川芎-当归不同配比(1:9,2:8~9:1)提取液后,模型大鼠体内5-HT、NO和NOS含量变化。结果:在不同配伍比例川芎当归给药后,模型大鼠脑内5-HT含量随川芎比例增加而增加,当川芎比例超过5:5是变化显著,达到8:2时变化最显著;NO而NOS含量变化差异不显著。结论:川芎当归药预防给药对能够减少脑内5-HT在偏头痛发作时的消耗,发挥收缩血管作用,且随着川芎比例增大,作用逐渐增强;阿魏酸对偏头痛的预防有效,但不是唯一有效成分,不能作为药对作用的决定因素。Objective： To investigate the effect of different proportion of Chuanxiong-danggui on endogenous substances of migraine rats. Methods： Subcutaneous injection of nitroglycerine suspension was used to establish the migraine rats. Changes in contents of three endogenous substances including 5-HT, NO and NOS in migraine rats were tested to observe the effects of different ration（1：9,2：8~9：1）of Ligusticum wallichii-Angelica sinensis extracts on migraine rats. Results： After administration with different ration of herb pairs mentioned above, content of 5-HT in brain of model rats was increased markedly following the increasing ration of Chuanxiong.This phenomenon occurred while the ration of Ligusticum wallichii exceed 5：5, especially it reached to 8：2; while there was no significant difference in contents of NO and NOS. Conclusion： Prophylactic administration of Chuanxiong-Danggui could decrease the 5-HT consumption during migraine fit, and then constricts blood vessels. Moreover, this function strengthend gradually with the increasing proportion of Ligusticum wallichii. Ferulic acid is effective on migraine, yet it is not the only effective component, thus it cannot be the function decisive factor.

关 键 词：川芎当归药对 偏头痛 5-HT NO NOS 

分 类 号：R33[医药卫生—人体生理学] R285.5[医药卫生—基础医学]