丝氨酸蛋白酶抑制剂PN-1的研究进展  

Study on Serine Protease Inhibitor PN-1

作　　者：郭振丰 李天时[1] 其力木格[1] 周婉祎 李雪连[1,3] 

机构地区：[1]哈尔滨医科大学药理教研室,黑龙江哈尔滨150081 [2]内蒙古民族大学第二临床医学院内蒙古林业总医院,内蒙古牙克石022150 [3]心血管药物研究教育部重点实验室黑龙江省生物医药工程重点实验室-省部共建国家重点实验室培育基地,黑龙江哈尔滨150081

出　　处：《现代生物医学进展》2017年第5期989-992,共4页Progress in Modern Biomedicine

基　　金：中国博士后科学基金第五批特别资助(2012T50355);黑龙江省博士后科研启动基金项目(LBH-Q13112)

摘　　要：丝氨酸蛋白酶抑制剂PN-1,由SERPINE2基因编码,是丝氨酸蛋白酶抑制剂超家族中的一员,是由多种细胞分泌的单链糖蛋白。PN-1在血浆中表达很少,但在多种器官和细胞类型中均有发现,在许多生物事件中发挥着重要的调节作用。PN-1在血液凝结、免疫反应、纤溶、血管发生、炎症和肿瘤抑制等一系列生理病理过程中发挥着重要作用。近年来对PN-1的研究,日益受到人们的关注,本文将主要综述PN-1在循环系统、肿瘤、神经系统以及肺部相关疾病中的最新研究进展及作用。Serine protease inhibitor protease nexin-1（PN-1） is encoded by the SERPINE2 gene.It belongs to a member of serine protease inhibitor superfamily, and is a kind of glycoprotein which is secreted by a variety of cells. PN-1 is a serpin that is barely detectable in the plasma but is discovered in many organs and cell types, which plays a key role in the physiological and pathological processes, such as the blood congealing, immunoreactions, plasmin fusion, inflammation and tumor suppressor. In recent years, the research of PN-1 has been paid more attention to. This article will summarize the latest research progress of PN-1 in the circulatory system, cancer,nervous system and lung-related diseases.

关 键 词：蛋白连接酶-1 丝氨酸蛋白酶抑制剂 肿瘤 神经 肺部相关疾病 

分 类 号：R966[医药卫生—药理学]