肠道病毒EV71手足口病病原学及免疫功能改变研究现状  

Research into the etiology and alterations in immunological function of hand,foot and mouth disease caused by Enterovirus 71

作　　者：王宇婧[1] 程邦宁[1] WANG Yujing CHENG Bangning(Pediatric Clinical College of Anhui Medical University （Anhui Province Children＇ s Hospital）, Hefei, Anhui China, 230051)

机构地区：[1]安徽医科大学儿科临床学院(安徽省儿童医院),安徽合肥230051

出　　处：《分子诊断与治疗杂志》2017年第2期127-131,共5页Journal of Molecular Diagnostics and Therapy

基　　金：安徽省卫生和计划生育委员会科研项目(14FR017)

摘　　要：手足口病(hand,foot and mouth disease,HFMD)是以手、足、口多发疱疹为主要特征的一类自限性疾病,5岁以下儿童多发,是由多种肠道病毒引起的儿童常见的急性传染性疾病。肠道病毒EV71是手足口病主要病原体,具有噬神经性,可引起患儿神经症状甚至死亡。本文将对EV71病原学特征、发病机制、感染后机体免疫功能改变进行讨论,以便更加深入了解EV71特征,为手足口病的防治提供依据。Hand, foot, and mouth disease（HFMD） is a self-limited disease characterized by multiple herpes of the hand, foot, and mouth, and caused by multiple enteroviruses in children under 5 years old.Enterovirus 71（EV71）is the major pathogen of HFMD, that can cause neurological manifestations and even death due to its neuronal apoptosis function. The purpose of this review is to summarize recent discoveries regarding the pathogen, etiopathogenesis, EV71-derived alterations in immunological function, and to provide guidance on preventing and curing HFMD.

关 键 词：手足口病 肠道病毒EV71 体液免疫 细胞免疫 

分 类 号：R725.1[医药卫生—儿科]