依托孕烯单根皮下埋植剂(Implanon~?)的月经模式变化和对痛经治疗的临床研究  

Contraceptive and dysmenorrheal relief efficacy of single rod etonogestrel implant(Implanon~?)

作　　者：平晟旻 顾逢春[2] 张祎 

机构地区：[1]上海市长宁区妇幼保健院妇产科,200050 [2]东南大学附属江阴市人民医院妇产科,无锡214400

出　　处：《中华生殖与避孕杂志》2017年第2期143-145,共3页Chinese Journal of Reproduction and Contraception

摘　　要：目的评估依托孕烯单根皮下埋植剂(Implanon?)的避孕效果、月经模式的改变和对痛经的治疗效果。方法以接受依托孕烯单根皮下埋植剂避孕的妇女200例为研究对象,术后随访24个月,分析其避孕效果,痛经缓解程度,不良反应和继用率。结果术后24个月,190例受试者完成随访,随访率95%。随访期间,无1例受试者意外怀孕,避孕率100%。另外,61例埋植前有痛经的受试者,55例埋植后痛经得到缓解,缓解率为90.2%。主要不良反应为月经模式改变141例(74.2%),包括不规则阴道流血60例(31.6%)、闭经6例(3.2%),经期延长63例(33.2%)、月经频发41例(21.6%);月经稀发20例(10.5%)、经量减少66例(34.7%)、经量增加10例(5.3%)。其他不良反应还有体质量增加32例(16.8%),痤疮21例(11.1%),激素相关不良反应63例(33.2%)。随访期间,16例受试者,包括阴道不规则流血(10例)、闭经(6例)提前取出植入剂,继用率为91.6%。结论依托孕烯单根皮下埋植剂的避孕效果好,有效缓解痛经程度,安全可靠,继用率高,可在临床上推广应用。Objective To evaluate the contraceptive and dysmenorrheal relief efficacy,and safety of single rod Etonogestrel implant （Implanon（R））.Methods A total of 200 females who received single rod Etonogestrel implant for contraception were enrolled.The participants were followed up for 24 months to evaluate the contraceptive efficacy,relief rate of dysmenorrheal,side effects and continuation rate of Implanon（R）.Results A total of 190 participants finished the 24-month follow-up.During the period,the contraceptive efficacy was 100%,and the relief rate of dysmenorrheal was 90.2%（55/61）.The maj or side effects were menstrual changes （141/190,74.2%）,including irregular bleeding （60/190,31.6%）,amenorrhea （6/190,3.2%）,prolonged bleeding （63/190,33.2%）,frequent bleeding （41/190,21.6%）,infrequent bleeding （20/190,10.5%）,decreased volume of bleeding （66/190,34.7%）,and increased volume of bleeding （10/190,5.3%）.Other side effects included gaining weight （32/190,16.8%）,acne （21/190,11.1%）,and hormone-associated side effects （63/190,33.2%）.During the follow-up,a total of 16 participants terminated implanon at an early stage,including 10 cases of irregular bleeding and 6 cases of amenorrhoea,yielding a continuation rate of 91.6%.Conclusion Single rod Etonogestrel implant （Implanon（R）） is effective and safe in contraception with relieved dysmenorrheal and a high continuation rate.

关 键 词：依托孕烯 避孕效果 安全性 继用率 

分 类 号：R711.51[医药卫生—妇产科学]