不明原因复发性流产免疫学发病机制的研究进展  

Research advances in the immunological pathogenesis of unexplained recurrent spontaneous abortion

作　　者：李莉[1] 乔杰[1] 王海燕[1] 

机构地区：[1]北京大学第三医院生殖医学中心,100191

出　　处：《中华生殖与避孕杂志》2017年第2期160-165,共6页Chinese Journal of Reproduction and Contraception

摘　　要：复发性流产发生率为1%~5%,其中40%~60%原因不明,称为不明原因复发性流产(unexplained recurrent spontaneous abortion,URSA)。近年研究表明,URSA的发生与免疫失衡关系密切,又称为同种免疫型复发性流产。本文论述URSA免疫学的发病机制、诊断、治疗的最新研究进展,重点论述了发病机制中免疫失衡方面的研究进展。Recurrent abortion occurs in 1%-5% couples,and among them 40%-60% cases have shown no clear etiology.Recent studies show URSA relates to imbalanced immune system closely,thus URSA is also regarded as alloimmune recurrent abortion.This review summarizes the research advances in immunological pathogenesis,diagnosis,and management of URSA and focuses on the insights into mechanism behind immune imbalance.

关 键 词：不明原因复发性流产(URSA) 机制 细胞因子 治疗 

分 类 号：R714.21[医药卫生—妇产科学]