睑板腺形态及功能与阻塞性睡眠呼吸暂停综合征的关系  

The correlation between meibomian gland abnormalities and obstructive sleep apnea-hypopnea syndrome

作　　者：刘木[1] 高莹莹[1] 赵华轩[1] 曾明范 陈晓阳[2] 

机构地区：[1]福建医科大学附属第二医院眼科,泉州362000 [2]福建医科大学附属第二医院呼吸内科,泉州362000

出　　处：《中华眼视光学与视觉科学杂志》2017年第2期111-116,共6页Chinese Journal Of Optometry Ophthalmology And Visual Science

基　　金：福建省中青年教师教育科研项目（JB13081）;福建医科大学教授基金（JS14030）

摘　　要：目的 探讨阻塞性睡眠呼吸暂停综合征（OSAHS）患者睑板腺形态结构及其泪膜稳定性的改变.方法 描述性研究.选取2013年11月至2014年6月期间于我院呼吸内科确诊为OSAHS的患者63例（126眼）作为OSAHS组,同期体检中心健康体检人群44例（88眼）作为对照组.对全部纳入对象询问个人基本信息及病史,并对眼表疾病指数（OSDI）进行评分后,再进行裂隙灯显微镜、非接触式红外线睑板腺成像仪、泪膜破裂时间（BUT）、睑板腺分泌物性状等眼部检查.结果 睑板腺缺失发生率在对照组,轻度、中度、重度OSAHS患者中分别为12/88（14％）、7/18 （39％）、14/30 （47％）、53/78 （68％）,组间差异有统计学意义（x2=50.62,P＜0.01）;轻度、中度、重度OSAHS患者睑板腺缺失评分分别为2.29＆#177;1.25、2.29＆#177;0.91、2.64＆#177;1.18,差异无统计学意义.对照组,轻度、中度、重度OSAHS患者中睑板腺扭曲发生率分别为8/88 （9％）、6/18（33％）、12/30（40％）,49/78 （63％）,组间差异有统计学意义（x=51.96,P＜0.01）.OSAHS组睑板腺开口堵塞发生率（69％）、分泌物性状改变发生率（72％）较对照组高（分别为36％、39％）,差异均有统计学意义（x2=22.42、27.26,P＜0.01）.结论 与正常人群比较,OSAHS患者泪膜稳定性较低,睑板腺萎缩及腺体的形态异常发生率较高,并且睑板腺的形态改变与OSAHS严重程度有关.Objective To discuss the relationship between meibomian gland abnormalities and tear film stability in patients with obstructive sleep apnea-hypopnea syndrome.Methods In a descriptive study from November 2013 to June 2014,63 patients （126 eyes） who were diagnosed with obstructive sleep apnea-hypopnea syndrome （OSAHS） were recruited.Healthy individuals （n=44;88 eyes） who were seeking physical examinations served as the control group.Personal information,clinical history,and the ocular surface disease index （OSDI） were recorded.All eyes were assessed by slit lamp examination,tear break-up time （BUT）,noncontact infrared meibography,and meibomian gland inspection.The prevalence of meibomian gland dropout and distortion in OSAHS patients was compared with controls.Results The prevalence of meibomian gland dropout in the control and different OSAHS groups （mild,moderate,and severe） was 12/88（14%）,7/18（39%）,14/30（47%）,and 53/78（68%）,respectively.The difference was statistically significant （x2=50.62,P〈0.01）.The meibography scores of the mild,moderate,and severe OSAHS group and the control group were 2.29＆#177;1.25,2.29＆#177;0.91,2.64＆#177;1.18,and 1.50＆#177;0.67,respectively.The difference was statistically significant.The prevalence of meibomian gland distortion in the control and different OSAHS groups （mild,moderate,and severe） was 8/88（9%）,6/18（33%）,12/30（40%）,49/78（63%）,respectively.The difference was statistically significant （x2=51.96,P〈0.01）.Meibomian gland orifices were plugged in 32 eyes in the control group （32/88,36%） and in 87 eyes in the OSAHS group （87/126,69%）.The difference was significant （x^22.42,P〈0.01）.Meibomian abnormalities were present in 34 eyes in the control group （34/88,39%） and in 91 eyes in the OSAHS group （91/126,72%）.The difference between the two groups were statistically significant （x2=27.26,P〈0.01）.Conclusion Compared to the general population,OSAHS patients have a less stable t

关 键 词：睑板腺功能障碍 阻塞性睡眠呼吸暂停综合征 睑板腺缺失 

分 类 号：R766[医药卫生—耳鼻咽喉科] R777.13[医药卫生—临床医学]