内侧杏仁核中催产素对布氏田鼠社会行为的影响  

Effect of Oxytocin in the Medial Amygdala on the Social Behavior of Lasiopodomys brandtii

作　　者：张楠[1] 闫立新[1] 高杰[1] 孙秀萍[1] 宋铭晶[1] ZHANG Nan YAN Lixin GAO Jie SUN Xiuping SONG Mingjing(Key Laboratory of Human Diseases Comparative Medicine, Ministry of Health, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences ＆ Comparative Medicine Center, Peking Union Medical College, Beijing 100021, China)

机构地区：[1]中国医学科学院医学实验动物研究所,北京协和医学院比较医学中心,卫生部人类疾病比较医学重点实验室,北京100021

出　　处：《四川动物》2017年第2期193-197,共5页Sichuan Journal of Zoology

基　　金：国家自然科学基金项目(31301890);农业虫害鼠害综合治理研究国家重点实验室开放研究基金项目(Chinese IPM1615)

摘　　要：目的探究内侧杏仁核(Me A)脑区中催产素(OT)对布氏田鼠Lasiopodomys brandtii社会行为的影响。方法在雄性布氏田鼠Me A区注射催产素受体拮抗剂后,采用社会识别实验、中央竞技场实验确定Me A区催产素受体的变化对其社会行为的影响。结果社会识别实验发现在Me A区注射人工脑脊液的布氏田鼠(对照组)对陌生鼠的探索时间显著长于探索熟悉鼠(0.001<P<0.01),而在Me A区注射催产素受体拮抗剂(实验组)对熟悉鼠和陌生鼠探索时间的差异无统计学意义(P>0.05),实验组对空笼、刺激鼠以及陌生鼠的探索时间都显著少于对照组(0.01<P<0.05);中央竞技场实验中实验组的攻击潜伏期和攻击时长与对照组的差异无统计学意义(P>0.05)。结论 Me A区中OT对布氏田鼠的社会记忆能力有影响,从而造成其社会识别障碍,但是对其社会性偏好和攻击行为都没有影响,说明OT在Me A区的表达是通过影响布氏田鼠的社会记忆进而影响其社会行为,而非改变布氏田鼠的亲社会性。Objective To explore the influence of oxytocin（ OT） in the medial amygdala（ Me A） on the social behaviors of Brandt＇s voles（ Lasiopodomys brandtii）. Methods Oxytocin receptor antagonist（ OTRA） was injected into the Me A of male Brants＇ s voles,and then the social behaviors were tested using social recognition experiment and neutral arena encounter experiment. Results The control group（ injected with artificial cerebrospinal fluid） took more time to explore the strangers than the familiars（ 0. 001 P 0. 01）. However,the experimental group took the similar time to investigate the strangers and the familiars（ P 0. 05）. And the experimental group spent significantly less time on empty cage,stimulus and strangers than that of the control group（ 0. 01 P 0. 05）. The experimental group showed similar attack time and incubation time of attack than the control（ P 0. 05）. Conclusion OT in Me A can influence the social recognition and memory ability of the Brandt＇s voles,but cannot affect its attack behavior. Therefore,it was concluded that the expression of OT in Me A could affect Brandt＇s voles＇ social behavior by impairing the ability of social memory,rather than changing their prosocial ability.

关 键 词：布氏田鼠 催产素 杏仁核 社会记忆 亲社会性 

分 类 号：Q958[生物学—动物学]