降钙素原和超敏C反应蛋白在肺炎并发脓毒血症患者的病情及预后评价中的价值  

Procalcitonin and Hypersensitive C Reactive Protein in the Prognosis of Pneumonia Patients Combined with Septicopyemia

作　　者：庞宗东 向永红[1] 梁世锋[1] 戴诗敏[1] 廖立新[1] 谢少娟[1] 张润娟[1] 唐海雄[1] 

机构地区：[1]广西壮族自治区民族医院/广西医科大学附属民族医院呼吸内科,广西南宁530001

出　　处：《医学新知》2017年第1期59-61,共3页New Medicine

摘　　要：目的 探讨降钙素原（PCT）与超敏C反应蛋白（hsCRP）用于评价肺炎并发脓毒血症患者的病情及预后的价值.方法 按照随机数字表法抽选2015年10月~2016年10月在我院就诊的肺炎并发脓毒血症的患者90例,按照病情的严重程度分成一般组、严重组与休克组,再按照脓毒血症患者在半个月中的死亡情况分为生存组与死亡组.另选取非脓毒症肺炎患者60例为对照组.结果 一般组、严重组与休克组的患者的PCT、hsCRP指标与APACHEⅡ分值均较对照组增加,差异有统计学意义（P〈0.05）,且一般组、严重组与休克组的患者的PCT、hsCRP指标与APACHEⅡ分值依次增加,组间差异显著（P〈0.05）.死亡组患者的PCT、hsCRP指标与APACHEⅡ分值均较生存组的增加,差异均有统计学意义（P〈0.05）.PCT、hsCRP与APACHEⅡ分值情况的诊断截点为≥2 ng/mL、≥75 mg/L以及≥11分.结论 PCT与hsCRP指标浓度的改变可在一定程度上反映肺炎并发脓毒血症患者的病情严重状况,P C T与h s C R P浓度可用于判断患者预后.Objective To investigate procalcitonin（PCT） and hypersensitive C reactive protein （hsCRP）in the prognosis of pneumonia patients combined with septicopyemia. Methods 90 pneumonia patients combined with septi- copyemia were randomly selected from Oct. 2015 to Oct. 2016. They were divided into general group, severe group and shock group according to severity. They were also divided into survival group and death group according to death status in half a month. 60 pneumonia patients without septicopyemia were set as control group. Restdts PCT, hsCRP and APACHEII scores increased more in general group, severe group and shock group than those in control group （ P 〈 0. 05 ）. PCT,hsCRP and APACHEII scores increased successively in general group,severe group and shock group（ P 〈 0.05 ）. PCT, hsCRP and APACHEII scores increased more in death group than those in survival group （P 〈 0.05 ）. The diagnostic cut - off point of PCT, hsCRP and APACHE II scores were more than 2 ng/mL,75 mg/L and 11 point. Conclusion Concentration changes of PCT and hsCRP index can reflect the severity of pneumonia combined with septicopyemia to a certain extent. Concentration of PCT and hsCRP can estimate the prognosis of patients.

关 键 词：降钙素原 超敏C反应蛋白 肺炎 脓毒血症 预后 

分 类 号：R563.1[医药卫生—呼吸系统]