四川地区451例儿童过敏原特异性IgE定量检测分析及临床意义  

The quantification and clinical significance of allergen specific IgE in 451 children from Sichuan Province

作　　者：沈川[1] 石华[1] 柳晓琴[1] 甘春玉[1] 李文胜[1] 

机构地区：[1]四川大学华西第二医院出生缺陷与相关妇儿疾病教育部重点实验室,成都610041

出　　处：《中华检验医学杂志》2017年第3期191-194,共4页Chinese Journal of Laboratory Medicine

摘　　要：目的探讨四川地区儿童特异性过敏原分布及规律，为临床诊疗提供依据。方法应用过敏原特异性IgE抗体检测试剂盒，采用酶联免疫捕获法，对于2016年4至8月在四川大学华西第二医院就诊的451例受试者进行20项过敏原的血清学检测，采用SPSS18.0进行统计分析其在不同性别、年龄和不同疾患者群中的特异性免疫球蛋白E（sIgE）水平。结果在检测的451例受试者中，过敏原阳性者282例，总体阳性率为62.53%。其中吸入性过敏原sIgE阳性者248例，阳性率为54.99%，食物性过敏原sIgE阳性者261例，阳性率为57.87%。吸入性过敏原中以屋尘螨最高（111例，24.61%），其次是粉尘螨（110例，24.39%），再次是屋尘（108例，23.95%）；食物性过敏原中阳性率最高的为牛奶（159例，35.25%）,其次是鸡蛋（111例，24.61%）。结论吸入性过敏原和食物性过敏原均是引起四川地区儿童过敏性疾病的重要原因，血清过敏原sIgE测定有利于了解患者的过敏状态，协助过敏性疾病的诊断。（中华检验医学杂志，2017, 40：191-194）Objective To explore the distribution of specific allergens for children in Sichuan Province and provide the evidences of clinical diagnosis and treatment. Methods Totally 451 cases in West China Second University Hospital, from April to August of 2016, were detected for 20 kinds of allergen- specific immunoglobulin E （IgE） by a new reverse enzyme-allergosorbent test, SPSS 18.0 statistical analysis was used to evaluate allergen-specific IgE levels in different groups of age, gender and diverse population distribution of disease. Results A total of 282 cases among 451 subjects were detected as IgE positive and the positive rate was 62.53%, among which 248 cases were positive for inhaled allergen-specific IgE, and the positive rate was 54.99%. There were 261 positive cases in food allergen-specific IgE, and the positive rate was 57.87%. For inhaled allergens, the highest positive rate was dermatophagoides pteronyssinus （n = 111, 24.61% ）, then dermatophagoidesfarina （ n = 110, 24.39% ）, and house dust （ n = 108, 23.95% ） ; For food allergens, the highest positive rate was milk （n = 159, 35.25% ） , then egg （n = 111,24.61% ） , and house dust （ n = 108, 23.95% ）. Conclusions Both Inhaled allergens and food allergens were the important cause of allergic disease for children in Sichuan area. Serum allergen specific IgE determination was helpful to understand the patient＇s allergy status, and diagnose the allergic disease. （ Chin J Lab Med, 2017, 40： 191-194）

关 键 词：变应原 免疫球蛋白E 酶联免疫吸附测定 

分 类 号：R725.9[医药卫生—儿科]