小电导钙激活钾通道促房颤自稳的机制研究进展  

Role of small conductance Ca^(2+)-activated K^+ channels in atrial electrical remodeling and atrial fibrillation self-stabilization:a review of mechanisms

作　　者：王安立[1] 殷亮[1] 王志农[1] 

机构地区：[1]第二军医大学长征医院胸心外科,上海200003

出　　处：《第二军医大学学报》2017年第3期355-359,共5页Academic Journal of Second Military Medical University

基　　金：上海市申康医院发展中心新兴前沿技术联合攻关项目(SHDC12014107)~~

摘　　要：心房颤动(房颤)是临床常见的心律失常,房颤易自发由阵发性向持续性乃至永久性发展,即房颤自稳现象,而心房电重构是房颤自稳过程中具有代表性的心房电生理改变。小电导钙激活钾通道(small conductance Ca^(2+)-activated K+channels,SK通道)是近年发现的广泛分布于心肌细胞中的离子通道,具有对胞内钙离子高敏感性的特点。SK通道在心房肌细胞的电重构中具有重要作用,尤其在促进房颤自稳并致使房颤持久化的机制中扮演了重要角色。本文旨在通过综述近年相关研究,总结SK通道促房颤自稳性的机制及相应的干预措施,并结合临床实际进行讨论。Atrial fibrillation（AF）is one of the most common types of arrhythmia in clinical practice.AF is prone to be permanent or even permanent AF from paroxysmal AF,which was called AF self-stabilization.Atrial electrical remodeling（AER）is a typical change of atrial electrophysiology in the AF self-stabilization process.Small conductance Ca^2＋-activated K^＋ channel（SK channel）is recently found and widely distributed in cardiac myocytes,and it is highly sensitive to Ca^2＋.Researches have shown that SK channels may affect AF self-stabilization through influencing the process of AER directly.This review aimed at summarizing the mechanisms of SK channels in the AF self-stabilization progress and the related intervention measures and discussing the role of SK channels in clinical practice.

关 键 词：小电导钙激活钾通道 心房颤动 心房电重构 持续性心房颤动 

分 类 号：R541.75[医药卫生—心血管疾病]