姜黄素抗肿瘤复发和转移作用研究进展  

Progress in Curcumin for Counteracting Recurrence and Metastasis of Tumor

作　　者：郭婷婷[1] 胡晨霞[1] 黄炜平 王洪琦[1] 

机构地区：[1]广州中医药大学,广东广州510006

出　　处：《中药新药与临床药理》2017年第2期253-256,共4页Traditional Chinese Drug Research and Clinical Pharmacology

基　　金：国家自然科学基金(81503301);广东省医学科研基金(A2016511);广州中医药大学出国留学人员薪火计划(XH20140115)

摘　　要：姜黄素是从姜科植物根茎中提取的一种植物多酚,近年来其抗肿瘤侵袭、复发和转移作用受到广泛关注。肿瘤复发、转移是一个复杂的、多因素调控的动态过程。研究表明,姜黄素能够抑制部分恶性肿瘤干细胞(Cancer stem cell,CSC)、上皮间充质转化(epithelial-mesenchymal transitions,EMT)、血管生成和血管生成拟态(vasculogenic mimicry,VM)等作用,有望为肿瘤复发和转移的防治提供新策略和发现新靶点。本文就其相关作用和机制作一综述,为深入研究姜黄素的抗肿瘤作用提供新方向。Curcumin is a kind of polyphenol extracted from the rhizome of Curcuma longa L.. In recent years,its anti-tumor effect has drawn extensive attention. It is known that the recurrence and metastasis of tumor is a complicated and multi-factor dynamic process. Studies show that curcumin has inhibitory effect on cancer stem cells（CSC）,epithelial-mesenchymal transition（EMT）,angiogenesis,vasculogenic mimicry（VM） and so on. Therefore,it has much potential to be an efficient agent for preventing and treating the invasion and metastasis of cancer. This article reviews the function and related mechanism of curcumin in treating cancer,which will provide a new direction for counteracting the recurrence and metastasis of tumor.

关 键 词：姜黄素 肿瘤干细胞 上皮间充质转化 间充质上皮转化 

分 类 号：R285.5[医药卫生—中药学]