沙格列汀联合二甲双胍对2型糖尿病的疗效与安全性分析  

Efficacy and Safety of Saxagliptin Combined with Metformin in the Treatment of 2 Type Diabetes

作　　者：刘瑞[1] 刘光金[2] 刘艳芬[1] 冯四平[1] 任竞[1] LIU Rui LIU Guang-jin LIU Yah-fen FENG Si-ping REN Jing(Pharmacy department, Yan＇an People＇s Hospital, Yan＇an, Shaanxi, 716000, China Pharmacy department, Yah＇an University Affiliated Hospital, Yan＇an, Shaanxi, 716000, China)

机构地区：[1]延安市人民医院药剂科,陕西延安716000 [2]延安大学附属医院药剂科,陕西延安716000

出　　处：《现代生物医学进展》2017年第6期1113-1116,共4页Progress in Modern Biomedicine

摘　　要：目的:探讨沙格列汀联合二甲双胍对2型糖尿病的疗效与安全性。方法:选取200例2型糖尿病患者,按随机数字表法分为两组,沙格列汀组(102例)口服沙格列汀联合二甲双胍治疗,阿卡波糖组(98例)口服阿卡波糖联合二甲双胍治疗。通过观察并记录治疗前后糖代谢情况与体重指数水平,SF-36量表各项评分,治疗期间不良反应情况,评价沙格列汀联合二甲双胍对2型糖尿病的疗效与安全性。结果:治疗后,两组HbAlc,BMI,FBG,2hPBG水平均明显下降(P<0.05),且沙格列汀组患者HbAlc,BMI,FBG,2 hPBG水平明显低于阿卡波糖组(P<0.05);治疗后3个月两组患者SF-36表各项评分均明显提高(P<0.05),但两组间差异没有统计学意义(P>0.05);随访期间,两组不良反应率相比,差异没有统计学意义(P>0.05)。结论:沙格列汀联合二甲双胍可以明显控制患者血糖水平,减轻患者体重,提高患者生活质量用药安全性好,值得临床推广使用。Objective：To investigate the efficacy and safety of saxagliptin combined with metformin in the treatment of 2 type diabetes.Methods：200 patients who had 2 type diabetes were selected and divided into two groups randomly.The patients in saxagliptin group（102 cases） were given saxagliptin combined with metformin,and the patients in acarbose group（98 cases） were given saxagliptin combined with metformin.The efficacy and safety of saxagliptin combined with metformin in the treatment of 2 type diabetes was evaluated by the detection of the indexes of glucose metabolism and body weight,SF-36 scores before and after treatment and adverse reactions during therapy.Results：After treatment,the HbA1 c,BMI,FBG,2hPBG level of two group were decreased（P〈0.05）,and the HbA1 c,BMI,FBG,2hPBG level of the saxagliptin group were lower than that of the acarbose group（P〈0.05）.After treatment,the SF-36 scores of two groups were increased（P〈0.05）,but there were no statistical significance on SF-36 scores between two groups（P〉0.05）.During treatment,there were no statistical significance on the incidence of adverse reactions between two groups（P〉0.05）.Conclusions：Saxagliptin combined with metformin can significantly control the blood glucose levels and improve the quality of life of patients with good safety,worthy of clinical application.

关 键 词：二甲双胍 沙格列汀 阿卡波糖 2型糖尿病 疗效 

分 类 号：R587.1[医药卫生—内分泌]