左金丸对胃肠道的调节作用  

Effects of traditional Chinese medicine Zuojin Pill on gastrointestinal system

作　　者：华晓东[1] 芮菁[1] 任变文 

机构地区：[1]天津药品检验所,天津300070 [2]天津合美医药科技有限公司,天津300308

出　　处：《药物评价研究》2017年第2期190-195,共6页Drug Evaluation Research

摘　　要：目的研究左金丸在胃肠道调节方面的作用。方法通过ig给予0.1%甲基橙溶液,计算其胃残留率,观察左金丸对小鼠胃排空的影响;通过ig 5%的炭末,计算炭末推进率,观察左金丸对正常小鼠小肠运动的影响、对新斯的明致小肠运动亢进的拮抗作用;观察左金丸对组胺致豚鼠离体回肠收缩的影响;ig给予大鼠D-木糖溶液,1 h后测定血清木糖值,观察左金丸对大鼠小肠吸收的影响;ig给予小鼠蓖麻油,观察左金丸的止泻作用。以戊己丸(加味左金)和黄连有效成份小檗碱作参比。结果左金丸对胃肠道有明显的调节作用,延长小鼠的胃排空时间,抑制胃排空;对正常小鼠小肠运动的无明显影响,但能明显拮抗新斯的明所致的小鼠小肠运动亢进;明显抑制组胺引起的豚鼠离体回肠收缩;明显抑制大鼠的小肠吸收功能;明显抑制蓖麻油造成的小鼠腹泻。结论古方左金丸对胃肠道有明显的调节作用,组方科学、合理。Objective To study the effects of traditional Chinese medicine Zuojin Pill on gastrointestinal system. Methods Through ig giving 0.1% methyl orange solution, the gastric residual rate was calculated, and the effect of Zuojin Pill on gastric emptying in mice was observed. By ig administration of 5% carbon powder, the advance rate of carbon powder was calculated, and the effect of Zuojin Pill on intestinal motility in normal mice and the antagonistic effect on intestinal motility hyperfunction induced by neostigmine were observed. Effect of Zuojin Pill on contraction of isolated guinea pig ileum induced by histamine was observed. After D-xylose solution was ig given to rats, the serum xylose level was determined 1 h later, and the effect of Zuojin Pill on rat intestinal absorption was observed. The anti-diarrhea effect of Zuojin Pill was observed by giving castor oil to mice. At the same time, we have made a comparison between Zuojin Pill and Wuji Pill-berberine, to evaluate the rationalization of Zuojin Pill. Results It was obvious in experimental results that Zuojin Pill had a regulating effect on gastrointestinal system. Zuojin Pill dose-dependently inhibited the gastric emptying. Zuojin Pill demonstrated more effective suppression on the accelerated movement induced by neostigmine, but did not inhibit normal intestinal transit in mice. Zuojin Pill markedly inhibited sperm motility in mice. Zuojin Pill concentration-dependently inhibited the contraction intensity of isolated ileum muscles in guinea pigs induced by histamine. Zuojin Pill markedly inhibited diarrhea induced by castor oil. Compared with Wuji Pill-berberine, the effect of Zuojin Pill on gastrointestinal system was more visible in the same dose. Conclusion Zuojin Pill has obvious regulation effect on the gastrointestinal tract, there are indications that the application of Zuojin Pill to clinic is scientific and reasonable.

关 键 词：左金丸 胃肠道 胃排空 小肠运动 回肠收缩 小肠吸收 腹泻 

分 类 号：R965[医药卫生—药理学]