鸦胆子油乳注射液不良反应的文献分析  

Literature analysis on adverse drug reactions induced by Brucea Jananica Oil Injection

作　　者：解丹[1] 尹寿祥[1] 姜鹏[1] 

机构地区：[1]马鞍山市人民医院药剂科,安徽马鞍山243000

出　　处：《药物评价研究》2017年第2期266-269,共4页Drug Evaluation Research

摘　　要：目的分析鸦胆子油乳注射液不良反应(ADR)的一般规律及特点,为临床合理用药提供依据。方法通过检索1990年1月—2016年9月中国学术期刊全文数据库、万方数据库、维普数据库等医药数据库,下载关于鸦胆子油乳注射液ADR的文献报道,并结合马鞍山市人民医院上报的4例ADR,进行统计和分析。结果共收集到76例ADR病例,其中老年患者多见,男性居多(61.84%),用药各时段均可发生ADR,最主要的表现为过敏反应(27.71%)、消化系统损伤(26.51%)和皮肤及其附件损伤(19.28%)。结论鸦胆子油乳注射液在临床应用中会引起多种ADR,其发生与多种因素相关,应加强对该药的合理使用及临床监测,保证用药安全。Objective To analyze the epidemiological characteristics of adverse drug reaction （ADR） induced by Brucea Jananica Oil Injection, through literature review and to provide theoretical support for rational use in clinic. Methods With retrospective case study, analyzed ADR induced by Brucea Jananica Oil Injection, which were searched from revelent domestic pharmaceutical database from January 1990 to September 2016. Results Totaliy 76 cases were collected, and most were middle-aged and aged patients. Males patients were more than female patients （61.84%）. ADR appeared in every period. The main ADRs of Brucea Jananica Oil Injection were allergic reactions （27.71%）, digestive system damage （26.51%）, and skin and accessories damage （19.28%）. Conclusion Brucea Jananica Oil Injection can induced various ADRs and the occurrence of ADRs was associated with a variety of factors. Clinical monitoring should be enhanced, so as to ensure safety and efficacy of medication.

关 键 词：鸦胆子油乳注射液 不良反应 文献分析 合理用药 

分 类 号：R969.3[医药卫生—药理学]