基于数据挖掘技术的含诃子藏药组方规律分析  

Analysis on composition principles of Tibetan medicine containing Terminalia chebula by data mining

作　　者：杨文娟[1] 泽翁拥忠[1] 张艺[1] 更藏加[1] 聂佳[1] 

机构地区：[1]成都中医药大学民族医药学院,四川成都611137

出　　处：《中国中药杂志》2017年第6期1207-1212,共6页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(81503362);国家社会科学基金项目(13XTQ012;16XMZ065)

摘　　要：该研究基于中医传承辅助平台(TCMISS),分析《中国医学百科全书——藏医学》、《藏医成方制剂现代研究与临床应用》、《常用藏成药诠释》等中含诃子藏药组方规律。应用该平台V2.5软件,将含诃子的方剂构建数据库,利用软件关联规则apriori算法、改进的互信息法等数据挖掘方法,分析含诃子藏药中的常用药物、药物组合频次、关联规则与核心药物组合等。对502首含诃子藏药分析后,总结出诃子常用药物组合14个,其所用药物多具有清热解毒、活血止痛、温中理气之功;主治疾病640种,其中使用频率较高(频率≥12)的有22种疾病。选择高频疾病"赤巴病"、"陈旧热症"、"食物中毒"对比分析得出诃子治疗不同疾病的核心药物组合。通过TCMISS对含诃子藏药进行统计分析,总结了诃子的临床组方规律和常用药物组合特点,为其临床应用和新药研发提供参考与新思路。This study using traditional Chinese medicine inheritance support software（TCMISS） to analyze the prescription rules of Tibetan medicine containing Terminalia chebula in the Encyclopedia of Chinese Medicine-Tibetan Medicine, Tibetan Medicine Composition Preparation of Modern Research and Clinical Application and Common Interpretation of Tibetan Medicine and so on. TCMISS （ V2. 5 ） was used to build a prescription database of Tibetan medicine containing T. chebula. The software statistical statement module, association rules and improved mutual information method and other data mining technologies were adopted to analyze the common herbs, combination rules and core combination of prescriptions containing T. chebula. Total 502 prescriptions containing T. chebula were analyzed and 14 common herbal combinations were summarized, whose ingredients mostly had the functions of clearing heat and detoxicating, promoting blood circulation and stopping pain, warming the middle-jiao and promoting the circulation of Qi. Prescriptions containing T. chebula were commonly used to treat 640 kinds of diseases, there are 22 kinds with high frequency（ 1〉 12） in which the representative ＂Tripa＂ disease, antiquated febrile symptoms, food poisoning had the highest frequency. T. chebula had different therapeutic effects through different compatibility. The complex composing and medication regularities of Tibetan medicine containing T. chebula have been clarified by TCMISS. That will provide reference for the clinical application of T. chebula and the new development.

关 键 词：诃子 藏药 中医传承辅助平台 组方规律 

分 类 号：R29[医药卫生—民族医学]