7.5%多杀霉素悬浮剂的制备与分析  

Preparation and Analysis of Spinosad 7.5% SC

作　　者：王娟[1] 张莎莎[1] 张保华[1] 李建忠[1] 梁生康[2] 孔祥平[1] 

机构地区：[1]青岛农业大学化学与药学院,山东青岛266109 [2]中国海洋大学海洋化学理论与工程技术教育部重点实验室,山东青岛266100

出　　处：《现代农药》2017年第2期17-20,共4页MODERN AGROCHEMICALS

基　　金：国家自然科学基金(31501682);山东省自然科学基金(ZR2014EL012;ZR2014CM039);青岛市应用基础研究计划项目(15-9-1-16-jch);青岛农业大学高层次人才科研基金(6631115037);青岛农业大学大学生科技创新基金

摘　　要：采用湿法研磨工艺,单因素优选法结合正交试验优化7.5%多杀霉素悬浮剂的制备条件,并采用高效液相色谱-质谱联用(HPLC-MS)法对热贮14 d产品进行质量检测。结果表明:以槐糖脂水溶液(200 mg/L)为分散介质,悬浮剂最优制备条件为Well-301和Well-303(质量比2∶1)用量6.0%,黄原胶用量0.25%,尿素用量4.5%,研磨时间2.0 h。热贮后有效成分组成和质量分数均保持不变,符合悬浮剂的要求。HPLC-MS法适用于多杀霉素类多组分混合物制剂的质量检测。The preparation conditions of spinosad 7.5% SC were optimized by single-factor test and orthogonal experiment using the wet grinding method. The stability of the product after heat storage for 14 d was determined by HPLC-MS. The results showed that the optimal preparation conditions were well-301 and well-303 （mass ratio 2 ： 1） 6.0%, xanthan gum 0.25%, urea 4.5% and a milling time of 2.0 h with sophorolipids aqueous solution （200 mg/L） as the dispersing medium. The composition and content of the active ingredients in the obtained product unchanged after heat storage for 14 d, and the prepared product met the requirements of SC. The HPLC-MS method may be suitable for the quality detection of multi-component pesticide formulations such as the spinosad SC.

关 键 词：多杀霉素 悬浮剂 槐糖脂 高效液相色谱一质谱 制备 

分 类 号：TQ450.7[化学工程—农药化工] O657.63[理学—分析化学]