2015年贵州省肺结核患者耐药监测情况分析  

Analysis of drug resistance surveillance of tuberculosis in Guizhou province in 2015

作　　者：沈欣[1] 雷世光[2] 宋沈超[1] 陈慧娟[2] 袁薇[2] 

机构地区：[1]贵州医科大学公共卫生学院,贵州贵阳550004 [2]贵州省疾病预防控制中心,贵州贵阳550004

出　　处：《临床肺科杂志》2017年第5期781-784,共4页Journal of Clinical Pulmonary Medicine

摘　　要：目的为了解贵州省结核病耐药情况,为贵州省结核病防治提供科学依据。方法在2015年1月至2015年12月期间收集结核分枝杆菌菌株,用比例法进行6种抗结核药物异烟肼(INH)、利福平(RFP)、链霉素(SM)、乙胺丁醇(EMB)、氧氟沙星(Ofx)、卡那霉素(Km)的药物敏感性测定。结果 716例结核分枝杆菌中总耐药率为18.6%,耐多药率为5.4%,其中初始耐药率为14.9%,获得性耐药率为24.3%,初始耐多药率为3.0%,获得性耐多药率为9.3%。获得性耐药率高于初始耐药率,差异有统计学意义(χ~2=9.913,P<0.05);获得性耐多药率高于初始耐多药率,差异有统计学意义(χ~2=13.157,P<0.01)。不同性别肺结核患者耐药率差异有统计学意义(χ~2=7.585,P<0.01)。各年龄段耐药率差异有统计学意义(χ~2=9.761,P<0.05)。结论贵州省结核病耐药水平较低,但耐药结核问题仍不能忽视,应进一步加强耐药结核病的监测与防治工作。Objective To understand the status of drug resistant in tuberculosis （TB） in Guizhou province, so as to provide scientific evidences for TB prevention and control. Methods Mycobacterium tuberculosis （MTB） were collected from January 2015 to December 2015, and were tested for drug resistance by proportional method with 6 kinds of anti-TB drugs, including isoniazide （ INH ） , streptomycin （ SM ） , rifampicin （ RFP ） , ethambutol （EMB）, ofloxacin （Ofx） and kanamycin （Km）. Results The total rate of drug resistant and multi-drug resistant （MDR） of 716 MTB were 18.6% and 5.4% , respectively. The rate of initial drug resistant and acquired drug resist- ant were 14. 9% and 24. 3% , respectively. The rate of initial MDR and acquired MDR were 3.0% and 9. 3% , re- spectively. The acquired drug resistant rate was higher than the initial drug resistant rate, and the difference was sig- nificant （χ2 =9. 913, P 〈0. 05）. The acquired MDR rate was higher than the initial MDR rate, and the difference was significant （ χ2= 13. 157, P 〈 0. 01 ）. There was statistical significance on drug resistant rate difference between gender of TB patients （χ2= 7. 585, P 〈 0. 01 ）. There was statistical significance on drug resistant rate difference a- mong each age of TB patients （ χ2 = 9. 761, P 〈 0. 05 ）. Conclusion The drug-resistant TB level is low in Guizhou province, but the problem of drug-resistant TB can＇t be ignored. We should enhance surveillance and control the drug-resistant tuberculosis.

关 键 词：结核病 耐药 监测 

分 类 号：R521[医药卫生—内科学] R181.3[医药卫生—临床医学]