扶正排毒方联合高效抗逆转录病毒疗法治疗艾滋病合并神经系统病变临床研究  

Fuzheng Paidu Formula Combined with Highly Active Anti-Retroviral Therapy in Treatment of AIDS with Neurologic Disorder

作　　者：沈露[1] 张金武[1] 朱建光[1] 

机构地区：[1]咸宁市中心医院,湖北科技学院附属第一医院,湖北咸宁437100

出　　处：《中医学报》2017年第3期313-317,共5页Acta Chinese Medicine

基　　金：湖北省自然科学基金重点项目(2012FFA064)

摘　　要：目的:研究扶正排毒方联合高效抗逆转录病毒疗法治疗艾滋病合并神经系统病变的临床疗效。方法:选择86例艾滋病合并神经系统病变患者作为研究对象,随机分为单纯治疗组和联合治疗组,每组各43例。单纯治疗组予以高效抗逆转录病毒治疗,联合治疗组在单纯治疗组基础上加用扶正排毒方联合治疗。比较治疗前、后两组患者外周血CD4+T淋巴细胞计数、中医证候积分、体质量、血常规的变化情况,评价临床疗效。结果:治疗后单纯治疗组与联合治疗组患者外周血CD4+T淋巴细胞计数均明显上升,而中医证候积分、白细胞、血红蛋白、血小板均明显下降,与治疗前比较,差异有统计学意义(P<0.05);和治疗前相比,单纯治疗组治疗后患者体质量明显下降,差异具有统计学意义(P<0.05);治疗后,联合治疗组患者的体质量未见明显变化(P>0.05);外周血CD4+T淋巴细胞计数、体质量均明显高于单纯治疗组,而中医证候积分明显低于单纯治疗组,差异具有统计学意义(P<0.05);联合治疗组有效率高于单纯治疗组,差异具有统计学意义(P<0.05)。结论:扶正排毒方联合高效抗逆转录病毒疗法治疗艾滋病合并神经系统病变效果显著,可提高患者的外周血CD4+T淋巴细胞计数,增强机体的免疫功能。Objective：To study the clinical efficacy of Fuzheng Paidu Formula combined with highly active anti-retroviral therapy in the treatment of AIDS with neurologic disorder. Methods ： Eighty-six cases of patients with AIDS and neurologic disorder admitted into our hospital from February 2012 to January 2014 were selected as the research objects, and were divided into two groups by drawing lots. Forty-three cases of patients in simple treatment group were treated with highly active anti-retroviral therapy, and the other 43 patients in combined treatment group were treated with Fuzheng Paidu Formula combined with highly active anti-retroviral therapy. The changes of peripheral blood CD4^＋ T lymphocyte counts, TCM syndrome score, weight and blood routine examination and clinical efficacy of patients in two groups before and after treatment were compared. Results ： Before treatment, the differences of peripheral blood CD4 ^＋ T lymphocyte counts, TCM syndrome score, weight, abnormal rate of WBC, HB and PLT of patients in both groups were not statistically significant （ P 〉 0.05 ） ; Compared with that of pre-treatment, peripheral blood CD4^＋ T lymphocyte counts of both groups after treatment all obviously increased, and TCM syndrome score, abnormal rate of WBC, HB and PLT all obviously decreased, with the differences being statistically significant （ P 〈 0.05 ） ; Compared with that of pre-treatment, the weight of patients in simple treatment group after treatment significantly decreased （ P 〈 0.05 ） ; Compared with that of pre-treatment, the weight of patients in combined treatment group after treatment had no obvious changes, with the difference not being statistically significant（P 〉 0.05 ） ;After treatment, peripheral blood CD4 ^＋T lymphocyte counts and weight of patients in combined treatment group were significantly higher than that of simple treatment group, and TCM syndrome score of combined treatment group was statistically lower than that of simple treatment group （ P 〈 0.0

关 键 词：艾滋病 神经系统病变 扶正排毒方 高效抗逆转录病毒疗法 中医药治疗 中西医结合 

分 类 号：R259.129.1[医药卫生—中西医结合]