中医药防治化学性肝损伤的研究进展  

Progress of TCM Studies in TCM Treatment of Liver Injury due to Chemical Factors

作　　者：付双楠 朱平生[1] 高达[1] 

机构地区：[1]河南中医药大学,河南郑州450046

出　　处：《中医学报》2017年第3期449-454,共6页Acta Chinese Medicine

基　　金：河南省杰出青年基金(154100510020);河南省高校科技创新团队支持计划(16IRTSTHN023);河南省属科研业务专项(2014KYYWF-22CX3-1)

摘　　要：中医药在治疗和预防肝脏疾病上有其独特的优势,其优势在于:1经济实惠,安全、不良反应少,易于大众接受;2治疗效果显著,不加重肝脏负担,显著提高患者生存质量;3不局限于某类药物,治疗种类多样化。但中医药防护化学性肝损伤也存在一些不足:1目前,学者对化学性肝损伤的中医辨证分型缺乏统一的标准,不利于形成统一的诊疗规范;2在临床研究中,样本量较小,缺乏较合理的试验设计方案;3中药复方多为个人经验方,缺乏临床观察数据,说服力不强;4中医药保肝机制尚不明确,需大量临床研究加以验证。在今后研究中,开发药食两用的中药及制剂、加强中医外治法的应用,对化学性肝损伤的治疗有不可忽视的作用,同时对化学性肝损伤的进一步研究应加强实验与临床应用的结合,注重整体观念与辨证论治,以充分体现中医药治疗化学性肝损伤的治疗优势及广阔前景。Chinese medicine in treatment and prevention of liver disease has unique advantages. （1）Being affordable, safe with fewer side effects and easy to be accepted by patients;（2）With significant clinical efficacy, without increasing the burden on the liver and being able to significantly improve the quality of patients＇ life;（3）Being not limited to certain types of drugs with diversified treatment methods. However, there are still some shortcomings of TCM treatment of the disease. （1）There is not a unified standard for TCM syndrome differentiation of the disease yet, which is not conducive to the formation of uniform diagnostic and therapeutic standards ; （2）In clinical researches, the sample size is small and there is a lack of reasonable experimental design ; （3）Chinese herbal compound prescriptions for the disease are based on personal experiences without adequate clinical observation data to convince its effectiveness. （4）The mechanism of liver protection of Chinese medicine is not yet clear, which requires to be verified by a large number of clinical studies. Therefore, the development of edible and medicinal productions the external therapy of TCM, as well as the combination of experiment and clinical practices should be the focus in future studies,in order to develop the syndrome differentiation and the treatment of liver injury due to chemical factors.

关 键 词：肝损伤 中药治疗 木蹄复方水提物 疏肝健脾方 补精复方 一贯煎合丹参 茵兰益肝颗粒 葛五护肝颗粒 

分 类 号：R259.75[医药卫生—中西医结合]