L-谷氨酸的胃肠道保护作用机制及药物开发  

Protective mechanisms of L-glutamate in gastrointestinal and drug development

作　　者：房凤玲 丁劲松[1] 

机构地区：[1]中南大学湘雅药学院,湖南长沙410013

出　　处：《药学学报》2017年第4期517-523,共7页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金资助项目(81573486)

摘　　要：L-谷氨酸是食物蛋白质的重要组成,在营养代谢、能量供应、免疫响应、氧化应激及信号通路调节等过程中发挥重要作用。近期研究发现,谷氨酸可预防非甾体抗炎药(NSAIDs)引起的胃肠道损伤,并可促进损伤的修复;可抑制幽门螺杆菌的定植、抑制NH_3引起的细胞凋亡,在非甾体抗炎药与幽门螺杆菌致消化道损伤与溃疡治疗中具有潜在的应用价值。本文对谷氨酸的代谢、生理作用,及其对非甾体抗炎药及幽门螺杆菌引起胃肠道损伤的保护机制进行了综述,以期为谷氨酸用于降低NSAIDs损伤及抗幽门螺杆菌致溃疡的相关药物研究开发提供参考。L-Glutamate is an important amino acid in protein. It has many physiological functions, such as nutrient metabolism, energy supply, immune response, oxidative stress, and signaling pathways regulation. Recent studies have found that glutamate prevents gastrointestinal damage induced by non-steroidal anti-inflammatory drugs （NSAIDs） and promotes the healing of the lesions. It can inhibit colonization of Helicobacter pylori and cell apoptosis caused by NH3. Hence, it has a potential value in protection of gastrointestinal from damage caused by NSAIDs and Helicobacterpylori. This article provides a review of the metabolism and physiological function of glutamate and its protective mechanisms of gastrointestinal injury caused by NSAIDs and Helicobacter pylori, which may serve as a reference in the study of glutamate in drug development.

关 键 词：谷氨酸 幽门螺杆菌 非甾体抗炎药 胃溃疡 保护作用 

分 类 号：R966[医药卫生—药理学]