低氧诱导因子-1在调控骨骼肌缺氧时能量代谢发生适应性变化的机制研究进展  

Recent progress on the mechanism of energy metabolism of hypoxia-inducible factor 1-driven skeletal muscle adaptations to hypoxia

作　　者：宋亚琼[1] 周播江[1] 

机构地区：[1]遵义医学院人体解剖学与组织学胚胎学教研室,贵州遵义563099

出　　处：《解剖学报》2017年第2期236-240,共5页Acta Anatomica Sinica

摘　　要：低氧诱导因子-1(HIF-1)是一种调控组织细胞氧稳态的关键性核转录因子,广泛存在于哺乳动物和人体内,其表达和活性受到细胞氧浓度的严密调控。它能在生理性和病理性缺氧缺血的情况下,通过调控细胞能量代谢、血管发生、红细胞生成、细胞生存、细胞增殖和凋亡等生物学效应,使细胞适应低氧环境得以生存或者走向凋亡。本文中我们主要概述了HIF-1的结构功能,及其在缺氧时调控骨骼肌能量代谢方面发生适应性变化的机制及研究进展。Hypoxia-inducible factor 1（ HIF-1） is a key nuclear transcription factor that regulates the oxygen homeostasis of tissue cells and widely exists in both mammals and humans. The expression and activity of HIF-1 are tightly regulated by cellular oxygen concentration. It can regulate the biological effects of cellular energy metabolism,angiogenesis,erythropoiesis,cell survival,cell proliferation and apoptosis in the physiological and pathological hypoxicischemic condition,so that the cells can adapt to the hypoxic environment to survive,or to apoptosis. This paper reviewed the structure and function of HIF-1 and the recent progress on the study of the mechanism of energy metabolism of HIF-1-driven skeletal muscle adaptations to hypoxia.

关 键 词：缺氧 低氧诱导因子-1 骨骼肌 能量代谢 

分 类 号：R322[医药卫生—人体解剖和组织胚胎学]