米索前列醇应用于产后出血的效果评价  

Effect evaluation of misoprostol on postpartum hemorrhage

作　　者：龚小斌 

机构地区：[1]广东省开平市妇幼保健计划生育服务中心,广东开平529300

出　　处：《中国医药科学》2017年第4期87-89,111,共4页China Medicine And Pharmacy

摘　　要：目的探讨产后出血患者行米索前列醇的效果,并分析其临床药理价值。方法选取我院2015年3月~2016年3月期间所收治的初产妊娠产妇210例,采用随机数字表法将210例患者平均分成A、B、C三组,每组各70例,其中A组患者行胎儿娩出后的缩宫素肌肉注射,B组患者在A组治疗基础上加行米索前列醇直肠给药模式,C组患者在A组治疗基础上加行米索前列醇舌下含服治疗,对三组产妇的产后120min以及2小时出血量进行记录。结果三组产妇经过相应模式的治疗后,均未出现产后出血情况,其中B组和C组患者的各个期间出血量要优于A组患者,差异有统计学意义(P<0.05)。B组和C组患者的数据对比,差异无统计学意义(P>0.05)。结论将米索前列醇联合缩宫素应用于产后出血的患者中,临床效果显著,且用药安全性高,这对于临床研究具有重要作用。Objective To explore the effect of misoprostol on postpartum hemorrhage,and to analyze its clinical pharmacological value. Methods 210 cases of primiparous pregnant women cured in our hospital from March 2015 to March 2016 were selected.According to random digital table method,they were averagely divided into group A,group B and group C with 70 cases in each.Patients in group A were treated with oxytocin intramuscular injection after fetus delivery,patients in group B were treated with misoprostol rectal administration model on the basis of group A,and patients in group C were treated with misoprostol sublingual therapy on the basis of group A.Postpartum 120min and 2 hour blood loss of the three groups were recorded. Results For mothers in the three groups,after the corresponding mode of treatment,there was no postpartum hemorrhage.Bleeding volume of patients in group B and group C were better than those in group A during each period, and the differences were statistically significant （P 〈 0.05）.There was no significant difference between B group and C group （P〉 0.05）. Conclusion The clinical effect of misoprostol combined with oxytocin in patients with postpartum hemorrhage is significant.And it has high safety of medication.h plays an important role in clinical research.

关 键 词：米索前列醇 产后出血 药理价值 效果分析 

分 类 号：R714.461[医药卫生—妇产科学]