抗结核治疗对非结核分枝杆菌肺病的疗效观察  

Efficacy of Antituberculosis Treatment for Nontuberculous Mycobacterial Lung Disease

作　　者：刘国标[1] 罗春明[1] 邓虹[1] 江万航[1] 

机构地区：[1]广州市胸科医院//广州市结核病防治所,广东广州510095

出　　处：《现代医院》2017年第3期354-356,共3页Modern Hospitals

基　　金：广东省省级科技计划项目(编号:2014A020212017);广州市科技计划项目(编号:2014Y2-00195);广州市医药卫生科技项目(编号:20151A011035)

摘　　要：目的观察抗结核治疗对非结核分枝杆菌(Nontuberculous Mycobacteria,NTM)肺病的疗效。方法对收治的NTM肺病患者80例,70例给予抗结核治疗,10例给予一般对症治疗,治疗后比较两者的疗效,同时把抗结核治疗的70例患者,根据分离的菌种分为快生长NTM组和慢生长NTM组,比较两组的疗效。结果治疗后抗结核治疗组与对症治疗组痰涂阴转率分别为83.3%和60.0%,痰培阴转率分别为53.0%和40.0%,临床症状有改善病例分别占57.6%和70.0%,胸片病灶有吸收或不变病例分别占81.8%和70.0%,这几方面的疗效比较差异无统计学意义(P>0.05)。快生长NTM组和慢生长NTM组痰涂阴转率分别为85.7%和71.4%,痰培阴转率分别为59.2%和38.1%,胸片病灶有吸收或不变病例分别占63.3%和52.4%,这几方面的疗效比较差异无统计学意义(P>0.05),临床症状有改善病例分别占87.8%和66.7%,差异有统计学意义(P<0.05)。结论抗结核治疗对NTM肺病患者疗效尚可,且对快生长NTM肺病的临床症状改善优于慢生长NTM肺病,但一般对症治疗对临床症状不明显的NTM肺病患者亦可取得满意疗效。Objective To observe the efficacy of antituberculosis treatment on patients with nontuberculous mycobac- terial（NTM） lung disease. Methods In 80 patients with NTM lung diseases, 70 cases were treated with antituberculosis therapy, and 10 cases were given general symptomatic treatment. The efficacies of the two groups were compared. Besides, the 70 cases were divided into fast - growing NTM group and slow - growing NTM group, and the efficacies were compared between the two groups. Results After treatment, the sputum smear negative rates of the two groups with antituberculosis treatment and general symptomatic treatment were, and the sputum cultivation negative rates were 53.0% and 40. 0% , re- spectively. 57.6% and 70. 0% of the cases had the clinical symptoms improved. 83.3% and 60.0% of them had the focus absorbed or unchanged. There was no statistical significance in the efficacy among the above aspects （P 〉 0. 05 ）. The spu- tum smear negative rates of fast - growing NTM group and slow - growing NTM group were 85.7% and 71.4% , the sputum cultivation negative rates were 59.2% and 38. 1% and the rates of focus absorbed or unchanged cases were 63.3% and 52.4% , respectively. There was no statistical significance among the above aspects （P 〉 0. 05）. 87.8% and 66. 7% of the patients had the clinical symptoms improved, the difference statistically significant （ P 〈 0. 05 ）. Conclusion The efficacy of antituberculosis therapy for the patients with NTM lung disease are acceptable, and the clinical symptoms improvement of fast - growing NTM group is better than slow - growing NTM group. However, general symptomatic treatment could achieve satisfactory results in NTM patients with no obvious clinical symptoms.

关 键 词：非结核分枝杆菌 治疗 预防控制 

分 类 号：R521[医药卫生—内科学]