Immunoscintigraphy with ^99mTc-Besilesomab in Aid to Fusiariosis Detection in Patients with Relapsed Acute Myeloid Leukemia （AML）： A Case Report and Literature Review  

作　　者：Elizabeth Campos de Moraes Juliana Moreira Silva Flavia Femanda Sichinelle Pessoa Luiz Antonio de Abreu Lauriano Pinheiro 

机构地区：[1]Diagnostic Center of Nuclear Medicine, Dimen at Bandeirantes Hospital Sao Paulo 01507-000, Brazil [2]Clinics Hospital of University of Sao Paulo Medical School Sao Paulo 01246-903, Brazil [3]Neuroscience and Applied Psychology, Mackenzie University, Sao Paulo 01302-907, Brazil

出　　处：《Journal of Pharmacy and Pharmacology》2017年第4期207-214,共8页药剂与药理学（英文版）

摘　　要：The aim of this article is to emphasize the importance of nuclear medicine in fungal infection characterization through a case report. Case： patient female, with AML-M2, hospitalized with fever, dyspnea, nausea, myasthenia, abdominal pain and diarrhea. In the physical examination exacerbated lesion in abdominal wall and subcutaneous nodules in upper and lower limbs. The computed tomography of the chest evinced area of attenuation in ground-glass opacities in the middle lobe, tending to consolidation and bilateral nodular opacities with ground-glass halo which suggested an infiammatory/infectious process of fungal etiology. Immunoscintigraphy with ^99mTc-besilesomab （Scintimun） identified focal infectious processes in activity, scattered over cutaneous and subcutaneous tissues, predominantly in extremities. In blood culture test, there was a growth ofFusarium sp. There is a difficulty in the diagnosis of fungal infections, both in clinical and imaging methods. There is no specific method to reaching the target. In addition, fungal diseases can be divided into focally localized or disseminated infections. There is a greater difficulty in the diagnosis of immunocompromised individuals due to the deficiency of basic defense mechanisms. Scintimun （scintigraphy with besilesomab） is a useful tool of nuclear medicine in the diagnosis of infectious and inflammatory diseases to allow the image of the whole-body and in vivo detection of early pathological and physiological phenomena, even before anatomical alterations occur.

关 键 词：IMMUNOSCINTIGRAPHY besilesomab nuclear medicine FUSARIOSIS fungal infections immunocompromised. 

分 类 号：S855.9[农业科学—临床兽医学] S858.292[农业科学—兽医学]