益肾清利活血法对肾虚湿瘀蛋白尿患者尿足细胞排泄的影响  

Effect of tonifying kidney,clearing away damp-heat and promoting blood circulation therapy for the excretion of urinary podocyte in proteinuria patients with type of kidney asthenia and damp stasis

作　　者：吴汉利[1] 孙伟[2] 

机构地区：[1]山东省潍坊市益都中心医院肾脏内科,山东青州262500 [2]江苏省中医院肾脏内科,江苏南京210029

出　　处：《中国医药导报》2017年第7期81-84,90,共5页China Medical Herald

基　　金：山东省中医药科技发展计划项目(2011-279)

摘　　要：目的观察益肾清利活血法对肾虚湿瘀蛋白尿患者尿足细胞排泄的影响。方法收集2011年7月~2015年7月潍坊市益都中心医院肾内科收治的肾虚湿瘀蛋白尿患者100例,按奇偶数将其随机分为益肾组和对照组,各50例。对照组采用常规治疗,益肾组在常规治疗的基础上采用肾清利活血法治疗,疗程15个月。采集患者治疗前后24 h尿蛋白定量、尿足细胞排泄、中医症状积分、安全性等指标,进行分析。结果治疗前两组患者尿足细胞数量、24 h尿蛋白、症状积分比较,差异无统计学意义(P>0.05)。治疗后益肾组尿足细胞数量、24 h尿蛋白量、症状积分均较治疗前显著降低,差异有高度统计学意义(P<0.01),且益肾组治疗后尿足细胞数量、24 h尿蛋白量、中医症状积分均显著低于对照组,差异均有统计学意义(P<0.05)。两组治疗后红细胞、白细胞、血小板、白蛋白、谷丙转氨酶比较,差异均无统计学意义(P>0.05)。结论益肾清利活血法可能是通过保护肾脏足细胞达到降低肾虚湿瘀蛋白尿患者尿蛋白的作用。益肾清利活血法可以明显改善患者临床症状,安全性较好,没有明显不良反应。Objective To investigate the effect of tonifying kidney, clearing away damp-heat and promoting blood circulation therapy for the excretion of urinary podocyte in proteinuria patients with type of kidney asthenia and damp stasis. Methods One hundred cases of proteinuria patients with type of kidney asthenia and damp stasis admitted to Department of Nephrology, Yidu Central Hospitol of Weifang City from July 2011 to July 2015 were collected, they were randomly divided into tonifying kidney group and control group by odevity, with 50 cases in each group. The control group was treated with conventional treatment, while the tonifying kidney group was treated with tonifying kidney, clearing away damp-heat and promoting blood circulation therapy on basis of conventional treatment. The course of treatment was 15 months. The 24 h urinary protein, excretion of urinary podoCytes, symptoms scores of traditional Chinese medieine and safety index between the two groups before and after treatment were eollected and analyzed. Results There were no significant differences of the number of urinary podocytes, 24 h urinary protein and symptom scores between the two groups before treatment （P 〉 0.05）. After treatment, the number of urinary podocytes, 24 h urinary protein and symptoms seores in tonifying kidney group were significantly lower than those before treatment （P 〈 0.01）, and the number of urinary podocytes, 24 h urinary protein and sYmPtom scores of the t0nifying kidney group after treatment were significantly lower than those of the control group （P 〈 0.05）. The differences of erythrocyte, leukocyte, platelet, albumin, alanine transaminase between the two groups after treatment were not statistically significant （P 〉 0.05）. Conclusion The tonifying kidney, clearing away damp-heat and promoting blood circulation therapy can reduce the urinary protein in proteinuria patients with type of kidney asthenia and damp stasis maybe through protecting the urinary podocyteg This method can obviously improve the

关 键 词：益肾清利活血法 肾虚湿瘀 24 h尿蛋白 尿足细胞 

分 类 号：R695.2[医药卫生—泌尿科学]