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机构地区:[1]上海交通大学医学院附属瑞金医院卢湾分院老年科,200020
出 处:《中华全科医师杂志》2017年第4期304-306,共3页Chinese Journal of General Practitioners
摘 要:回顾分析2015年6月1日至2015年12月31日185例行甲状腺切除术患者的临床资料。术后病理检查示,86例为甲状腺恶性结节(恶性结节组), 99例为良性结节(良性结节组)。两组超声示结节边界不清[51%(44/86)与16%(16/99)]、结节内低回声[(95%(82/86)与27%(27/99)]、微钙化[63%(54/86)与21%(21/99)]、颈部淋巴结肿大[33%(28/86)与5%(5/99)]比较,差异均有统计学意义(均P〈0.05)。甲状腺结节超声评估系统(TI-RADS)分级诊断甲状腺恶性结节的敏感度为77%(66/86),特异度为86%(85/99),阳性预测值为83%(66/80),阴性预测值为81%(85/105),诊断准确性为82%(151/185)。恶性结节组抗甲状腺球蛋白抗体(TGAb)、抗甲状腺过氧化物酶抗体( TPO-Ab)阳性率为6%(5/79)和25%(20/79),高于良性结节组的0和12%(11/94)(均P〈0.05);两组游离T3 、游离T4、TSH水平[(4.91±0.78)比(4.93±1.98) pmol/L、(13.57±2.22)比(13.58±2.17) pmol/L、(1.783±1.404)比(1.88±2.36) mU/L]比较,差异均无统计学意义(均P〉0.05)。提示TI-RADS分级及甲状腺免疫指标对甲状腺结节鉴别有价值。The clinical data and ultrasound findings of 185 patients with thyroid nodules undergoing thyroidectomy from June to December 2015 were retrospectively reviewed. Postoperative pathology confirmed malignant thyroid nodules in 86 cases and benign nodules in 99 cases. The ultrasonographic findings showed that there were significant differences in obscure boundary [51% (44/86) vs. 16% (16/99)] , hypoecho [ (95% (82/86) vs. 27% (27/99) ], internal micro-calcification [63% (54/86) vs. 21% (21/99) 1 and lymph node enlargement [33% (28/86) vs. 5% (5/99)] between malignant and benign nodules ( all P 〈 0. 05). The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of thyroid imaging reporting and data system (TI-RADS) in differentiation of malignant and benign thyroid nodules were 77% (66/86), 86% ( 85/99 ), 83% ( 66/80 ), 81% ( 85/105 ) and 82% ( 151/185 ), respectively. The positive rates of thyroid globulin antibody(TGAb) and thyroid peroxydase antibody( TPO- Ab) in malignant nodules [6% (5/79)and 25% (20/79)] were significantly higher than those in benign nodules [0 (0/94) and 12% (11/94)1 (both P 〈0.05). There was no significant difference in free T3 ( FT3 ) , free T4 ( FT4 ) and TSH between the two groups [ (4.91 ±0.78 ) vs. (4.93 ± 1.98 ) pmol/L, (13.57 ±2.22) vs. (13.58 ±2.17)pmol/Land(1.78±1.40) vs. (1.88±2.36)mU/L] (all P〉0.05). The results indicate that TI-RADS grading and thyroid immunity index are valuable for differential diagnosis of thyroid nodules.
分 类 号:R445.1[医药卫生—影像医学与核医学] R581[医药卫生—诊断学]
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