中药单体成分逆转肿瘤多药耐药的研究进展  

Research progress on Chinese materia medica monomers reversing multidrug resistance of tumor cells

作　　者：汤涛[1] 董伟[1] 张婧[1] 赵国巍[1] 管雪静 廖正根[1] 梁新丽[1] 陈静[2] TANG Tao DONG Wei ZHANG Jing ZHAO Guo-wei GUAN Xue-jing LIAO Zheng-gen LIANG Xin-li CHEN Jing(Key Laboratory of Modem Preparation of Traditional Chineses Medicine, Ministry of Education, Jiangxi University of Traditional Chineses Medicine, Nanchang 330004, China The First Clinical Medical College of Nanchang University, Nanchang 330031, China)

机构地区：[1]江西中医药大学现代中药制剂教育部重点实验室,江西南昌330004 [2]南昌大学第一临床医学院,江西南昌330031

出　　处：《中草药》2017年第4期792-797,846,共7页Chinese Traditional and Herbal Drugs

基　　金：国家青年自然科学基金项目(81303237);中国博士后科学基金(2016M590606);"赣鄱英才555"工程领导人才培养计划(赣财教指[2013]296号);江西省青年科学家培养对象(20153BCB23019);青年科学基金(20161ACB21020)

摘　　要：肿瘤的多药耐药性(multidrug resistance,MDR)是导致肿瘤化疗失败的重要原因之一。中药单体成分因其高效低毒、多靶点、价廉等特性已逐渐在逆转肿瘤多药耐药中得到了重视。以肿瘤多药耐药的相关机制为切入点,对近年来中药单体成分在逆转肿瘤多药耐药中的研究进行归纳总结,中药单体成分在逆转肿瘤多药耐药方面具有重要的研究意义。Multidrug resistance （MDR） is one of the major causes of failure of chemotherapy for tumor. Chinese materia medica （CMM） monomers which can reverse MDR have been paid more and more attention to because of the high efficiency, low toxicity, multiple targets, and low price. This paper made the MDR mechanisms as the breakthrough point and summarized the research on CMM monomers reversing MDR of tumor. The results show that the monomer component of CMM reversing MDR of tumor has important significance.

关 键 词：肿瘤 多药耐药性 中药单体成分 逆转肿瘤多药耐药 细胞凋亡 

分 类 号：R285[医药卫生—中药学]