裸花紫珠化学成分与药理活性研究进展  

Research progress on chemical constituents in Callicarpa nudiflora and their pharmacological activities

作　　者：冯世秀 张旻 易博[2] 吴洪新[3] FENG Shi-xiu ZHANG Min YI Bo WU Hong-xin(Key Laboratory of Southern Subtropical Plant Diversity, Shenzhen Fairy Lake Botanical Garden, Chinese Academy of Sciences Shenzhen 518004, China Department of Pharmacy, 187 Hospital of PLA, Haikou 571159, China Grassland Research Institute of CAAS, Huhhot 010010, China)

机构地区：[1]深圳市中科院仙湖植物园深圳市南亚热带植物多样性重点实验室,广东深圳518004 [2]中国人民解放军第187中心医院药剂科,海南海口571159 [3]中国农业科学院草原研究所,内蒙古呼和浩特010010

出　　处：《中草药》2017年第5期1015-1026,共12页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金基金资助项目(31500284);海南省自然科学基金资助(20158276)

摘　　要：裸花紫珠为海南省的道地药材,并被录入《中国药典》2015年版新增中药品种。通过对国内外1996—2016年文献调研显示,其化学成分主要有苯丙素类、黄酮类、三萜类、二萜类、环烯醚萜类、酚酸类及其苷和甾醇等。现代药理活性研究表明其具有止血、抗炎、抑菌、增强免疫、细胞毒等作用。通过完成对裸花紫珠的化学成分系统总结和药理活性的概述,为其药材的质量控制、药理作用研究和深层次开发利用提供参考依据。Callicarpa nudiflora is the genuine medicinal material in Hainan province, and is successfully approved as a new variety in Chinese Pharmacopoeia 2015. Based on a detailed investigation on the literature reports at home and abroad from 1996 to 2016, we have found that the principal chemical constituents were recognized as phenylpropanoids, flavonoids, phenolic acids, triterpenoids, diterpenoids, iridoids, sterols, etc. The biological activities of chemical constituents from C. nudiflora were mainly studied on the hemostasis, anti-inflammation, anti-bacterial, immune-strengthening, and cytotoxic activities. The present paper systematically summarized the previously phytochemical work of C. nudiflora, and the biological activities were also reviewed briefly. The current paper provides the references for the further quality control, pharmacological action study, and utilization of this medicinal plant.

关 键 词：裸花紫珠 苯丙素类 黄酮类 三萜类 止血 抗炎活性 

分 类 号：R282.71[医药卫生—中药学]