热毒宁注射液化学成分、药理作用及临床应用研究进展  

Research progress on chemical constituents,pharmacological action,and clinical application of Reduning Injection

作　　者：葛雯[1] 李海波[2] 于洋[2] 房卉[1] 姚新生[2] GE Wen LI Hai-bo YU Yang FANG Hui YAO Xin-sheng(Nanjing University of Chinese Medicine, Nanjing 210046, China Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou 510632, China)

机构地区：[1]南京中医药大学,江苏南京210046 [2]暨南大学中药及天然药物研究所,广东广州510632

出　　处：《中草药》2017年第5期1027-1036,共10页Chinese Traditional and Herbal Drugs

基　　金："重大新药创制"科技重大专项(2013ZX09402203);江苏省自然科学青年基金:基于活性成分追踪分离及快速检识分析新策略的中药复方药效物质基础研究(BK20140441);江苏省博士后科研资助计划(1401171C);国家中药标准化项目(ZYBZH-C-JS-31)

摘　　要：热毒宁注射液具有清热、疏风、解毒的功效,临床上主要用于治疗外感风热所致的感冒、咳嗽及上呼吸道感染、急性支气管炎等,其临床疗效确切,安全性好,应用广泛。热毒宁注射液的化学成分主要包括环烯醚萜类、木脂素类、香豆素类、倍半萜类、黄酮类、咖啡酰奎宁酸类、酚酸类等。通过查阅近几年与热毒宁注射液相关的国内外文献,对其化学成分、药理作用及临床应用进行综述。Reduning Injection（RI） has the effects of clearing heat, dispelling wind, and detoxification. It has been proved to be widely used for the treatment of wind-heat cold, cough, fever, upper respiratory tract infection, and acute bronchitis with good therapeutic effect and high security in clinical practice. Main chemical composition of RI includes iridoids, lignans, coumarins, sesquiterpenoids, flavonoids, coffee acyl quinine acids, phenolic acids, etc. This paper reviews domestic and foreign researches about RI in recent years and summarizes the chemical constituents, pharmacological action, and clinical application.

关 键 词：热毒宁注射液 环烯醚萜类 木脂素类 香豆素类 倍半萜类 黄酮类 咖啡酰奎宁酸类 解热 抗炎 抗病毒 

分 类 号：R284[医药卫生—中药学] R285[医药卫生—中医学]