素心腊梅种子中1个新生物碱  

A new alkaloid from seeds of Chimonanthus praecox var. concolor

作　　者：张春艳[1] 白雪梅[1] 张旭[1] 秦玉琴[1] 石继祥[1] 李羽晗 王欣[1] 陆世惠[1] 黄静[1] 

机构地区：[1]四川大学华西药学院,四川成都610041

出　　处：《中草药》2017年第6期1072-1075,共4页Chinese Traditional and Herbal Drugs

摘　　要：目的研究素心腊梅Chimonanthus praecox var.concolor种子中的化学成分。方法采用柱色谱和重结晶法进行分离纯化并采用质谱、核磁共振等技术鉴定化学结构。结果从素心腊梅种子95%乙醇提取物中分离鉴定了8个化合物,包括1个新化合物素心腊梅碱(1),1个新天然产物N1,N10-二甲基吲哚基乙胺(2)以及6个已知化合物:10-二十一碳烯酸(3)、β-谷甾醇(4)、β-胡萝卜苷(5)、胡萝卜苷亚油酸酯(6)、东莨菪素(7)和对羟基桂皮醛(8)。结论化合物1为新生物碱类化合物,命名为素心腊梅碱,2为首次从天然界发现的化合物。其他所有化合物均为首次从该植物中得到。Objective To investigate the chemical constituents in the seeds of Chimonanthus praecox var. concolor. Methods The column chromatography and recrystallization methods were used for the isolation and the purification of compounds, and the spectroscopic methods（MS, NMR, etc.） were used for the structural identification. Results A new alkaloid chimonanthconin（1） and a new natural compound N1,N10-dimethyltryptamine（2）, along with six known compounds, 10-heneicosenoic acid（3）, β-sitosterol（4）, β-daucosterol（5）, daucoster linoleate（6）, scopoletin（7）, and p-hydorxyleinnamaldehyde（8）, were isolated and identified. Conclusion Compound 1 is a new alkaloid and named chimonanthconin and compound 2 is a new natural compound. And other compounds are isolated from this plant for the first time.

关 键 词：腊梅科 素心腊梅 种子 素心腊梅碱 N1 N10-二甲基吲哚基乙胺 

分 类 号：R284.1[医药卫生—中药学]