血必净注射液对重症肺炎患者血浆IL-6和TNF-α水平的影响  

Effect of Xuebijing Injection on expression of interleukin-6 and tumor necrosis factor-α in patients with severe pneumonia

作　　者：刁云锋[1] 张士俊 赵万勇[1] 孙洪涛[1] 张赛[1] 孙亮[3] 

机构地区：[1]武警后勤学院附属医院脑科医院武警部队脑创伤与神经疾病研究所天津市神经创伤修复重点实验室,天津300162 [2]天津北辰医院神经外科,天津300400 [3]武警后勤学院附属医院呼吸与重症医学科,天津300162

出　　处：《中草药》2017年第6期1188-1191,共4页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(81271392);天津市自然科学基金资助项目(12JCYBJC18500)

摘　　要：目的探讨血必净注射液对重症肺炎患者血浆中白细胞介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)的影响。方法将100例重症肺炎患者按随机数字表法分为对照组(50例)和治疗组(50例)。两组均给予常规西医治疗,治疗组在常规西医治疗的基础上加用血必净注射液治疗,连续用药7 d。取10名身体健康的人员作为正常对照组。比较对照组和治疗组患者治疗前后体温、白细胞计数(WBC)、C反应蛋白(CRP)、动脉血氧分压[pa(O_2)]和动脉血气分析氧合指数[pa(O_2)/Fi(O_2)]的变化。采用ELISA法测定并比较各组患者各时间点血浆中IL-6和TNF-α的水平。结果治疗7 d后,治疗组和对照组患者的体温、WBC、CRP、pa(O_2)和pa(O_2)/Fi(O_2)均较治疗前有明显改善,差异显著(P<0.01)。治疗组患者治疗后各项指标均较对照组治疗后有明显改善,差异显著(P<0.05、0.01);对照组和治疗组患者治疗前后血浆中IL-6和TNF-α均明显高于正常对照组。治疗前,对照组和治疗组患者血浆中IL-6、TNF-α的水平相比较,差异无统计学意义;两组患者治疗后3、7 d的IL-6和TNF-α水平均较治疗前降低,治疗组IL-6和TNF-α水平的下降程度较对照组同期更明显,差异显著(P<0.05、0.01)。结论血必净注射液可以降低重症肺炎患者血浆中IL-6和TNF-α水平,对重症肺炎患者有一定辅助治疗作用。Objective To observe the effect of Xuebijing Injection on the expression of interleukin-6（IL-6） and tumor necrosis factor-α（TNF-α） in patients with severe pneumonia. Methods Totally 100 patients with severe pneumonia were randomly assigned to the conventional treatment group（n = 50） and Xuebijing treatment group（n = 50）. Each group was given conventional treatment, while in the Xuebijing treatment group, Xuebijing Injection was additionally given for consecutive 7 d. Ten healthy people were chosen as normal control group. The changes of patients＇ body temperature, white blood cell count, C-reactive protein, arterial oxygenation, and oxygenation index in two groups were compared. The expression levels of IL-6 and TNF-α were detected by ELISA method at different time points. Results In conventional treatment group and Xuebijing treatment group, the patients＇ body temperature, white blood cell count, C-reactive protein, arterial oxygenation, and oxygenation index were significantly improved after treatment（P 0.01）. Compared with conventional treatment group, in Xuebijing treatment group, these indicators were significantly improved after treatment（P 0.05 or 0.01）. Compared with normal control group, in conventional treatment group and Xuebijing treatment group, the expression levels of IL-6 and TNF-α were significantly higher. Compared with the conventional treatment group, in Xuebijing treatment group, the expression levels of IL-6 and TNF-α had no significant difference before the treatment. On days 3 and 7 after Xuebijing administration, the expression levels of IL-6 and TNF-α decreased than those before the treatment. The expression levels of IL-6 and TNF-α in Xuebijing treatment group significantly decreased than those in the conventional treatment group. Conclusion Xuebijing Injection can reduce the levels of IL-6 and TNF-α in patients with severe pneumonia, thus this agent has certain auxiliary therapeutic effect in the treatment of patients with severe pneumonia.

关 键 词：血必净注射液 重症肺炎 白细胞介素-6 肿瘤坏死因子-α 中西医结合疗法 

分 类 号：R563.1[医药卫生—呼吸系统]