沙尘暴PM_(2.5)生物学效应及作用机制研究进展  

Research advances on biological effects and potential toxicity mechanisms of dust storm fine particles

作　　者：钟建斌[1] 雷泽林[2] 唐艳[3] 张丹[1] 刘举科[4] 马建秀[1] 

机构地区：[1]西北民族大学医学院,甘肃兰州730030 [2]兰州大学第一医院呼吸科,甘肃兰州730000 [3]兰州大学第一医院中心实验室,甘肃兰州730000 [4]兰州城市学院,甘肃兰州730070

出　　处：《环境与职业医学》2017年第3期280-284,共5页Journal of Environmental and Occupational Medicine

基　　金：国家自然科学基金(编号:31260133);西北民族大学2015年国家级大学生创新创业训练计划项目(编号:201510742088)

摘　　要：沙尘暴PM_(2.5)是造成大气污染和危害人体健康的重要因素之一。沙尘暴PM_(2.5)组成成分复杂,影响范围广,进入机体潜在致敏靶点可引起多种健康损伤。本文概述近年来沙尘暴PM_(2.5)导致机体生物学效应及相关机制的研究现状,包括炎性作用、氧化应激、免疫毒性、DNA损伤等,旨在为进一步深入研究沙尘暴PM_(2.5)造成的生物学效应及具体作用机制提供依据。Dust storm fine particles （PM2.5） are one of the major factors resuhing in air pollution and threatening human health. Owing to complex components and a wide coverage, dust storm PM2.5 can cause multiple adverse health effects through potential sensitive targets. In this paper, recent studies reporting the biological effects and potential mechanisms of toxicity induced by dust storm PM2.5 exposure were reviewed and presented from four perspectives including inflammatory response, oxidative stress, immune toxicity, and DNA injury. This review aimed to provide a theoretical basis for further related studies.

关 键 词：沙尘暴 细颗粒物 炎性作用 氧化应激 免疫毒性 DNA损伤 

分 类 号：R122[医药卫生—环境卫生学]