甲状旁腺功能减退症患者过量维生素D导致高钙危象一例报告  

Hypercalcemic crisis caused by large dose of vitamin D in a patient with hypoparathyroidism:a case report

作　　者：吕芳[1] 徐晓杰[1] 宋玉文[1] 李路娇 王鸥[1] 姜艳[1] 夏维波[1] 邢小平[1] 李梅[1] 

机构地区：[1]中国医学科学院北京协和医学院北京协和医院内分泌科国家卫生和计划生育委员会内分泌重点实验室,北京100730

出　　处：《中华骨质疏松和骨矿盐疾病杂志》2017年第2期150-154,共5页Chinese Journal Of Osteoporosis And Bone Mineral Research

基　　金：国家自然科学基金面上项目(81570802)

摘　　要：甲状旁腺功能减退症患者需要长期服用钙剂和维生素D制剂。本文分析1例甲状腺全切术后甲状旁腺功能减退症患者长期治疗过程中,未规律监测血液生化指标,也未调整钙剂及维生素D制剂剂量,出现高钙危象、肾脏钙质沉着和肾功能损害等维生素D中毒表现,经过水化、利尿、降钙素治疗后,血钙降至正常。本病例报告旨在提醒临床医师重视罕见的维生素D中毒现象,并关注其治疗措施。Patients with hypoparathyroidism need to receive long-term treatment with calcium and vitamin D supplements. We reported a case of vitamin D intoxication in a patient with hypoparathyroidism after total thyroidectomy. She presented with hypercalcemic crisis, nephrocalcinosis, and renal function impairment, because serum and urinary calcium level were not monitored during treatment and the dose of calcium and vitamin D supplements were not adjusted accordingly. Hypercalcemic crisis was alleviated with treatment of fluid replacement, furosemide, and calcitonim. Rare vitamin D intoxication should be taken seriously and treated properly.

关 键 词：甲状旁腺功能减退症 维生素D中毒 高钙危象 

分 类 号：R582[医药卫生—内分泌]