195例淀粉样变性肾病临床病理学相关因素分析  

Logistics Regression Analysis of 195 Cases of Amyloidosis Nephropathy

作　　者：林峥[1] 林春[1] 江辉[1] 郭春花[1] 邓金秀[1] 

机构地区：[1]福建医科大学附属龙岩第一医院肾内科,福建龙岩364000

出　　处：《湖北医药学院学报》2016年第6期561-565,共5页Journal of Hubei University of Medicine

摘　　要：目的:分析淀粉样变性肾病(amyloidosis nephropathy,ANP)临床病理学特征的影响因素。方法:回顾分析2006年5月至2015年5月福建医科大学附属龙岩第一医院肾内科检查确诊的195例淀粉样变性肾病患者临床资料,依据临床表现将其分为蛋白尿期、肾病综合征期、肾功能不全期3组,观察3组病理指标与临床指标的关系,采用Logistic非条件多因素回归分析临床病理学特征的相关因素。结果:淀粉样变性肾病患者尿蛋白定量(24 h urinary protein excretion,UPE)水平在Logistic多因素回归分析中无统计学意义(P>0.05),HGB、Scr、e GFR水平为淀粉样变性肾病患者病理改变的相关因素(P<0.05)。结论:应高度关注ANP患者HGB、Scr、e GFR水平,参考三者水平变化,预判可能出现的肾小球淀粉样蛋白沉积、淀粉样蛋白肾血管及肾间质沉积、肾间质纤维化与肾小管萎缩、肾间质炎性细胞浸润等病理特征性改变,为早期制定合理化、规范化综合治疗方案提供依据。Objective To study the influence factors of clinical pathological characteristics of amyloid nephropathy. Methods Total 195 patients with amyloidosis nephropathy from May 2006 to May 2015 in Our department were selected, and the clinical data of them were retrospectively analyzed. According to the clinical manifestation, the patients was divided into proteinuria group, nephrotic syndrome group, renal insufficiency group. The relationship between pathological and clinical indexes was assessed by Logistic multivariate regression analysis. Results The level of UPE in different stage of amyloidosis nephropathy had no statistical difference （P〈0.05）. Multivariate Logistic regression analysis showed HGB, Scr and eGFR levels were the risk factors of pathological in patients with amyloidosis nephropathy（P〈0.05）. Conclusion HGB, Scr and eGFR levels should be high concerned in the amyloidosis nephropathy patients. According to the change of HGB, Scr and eGFR, it was helpful to prognosis of some pathological character, such as amyloid deposits in the glomerular mesangial area, capillary basement membrane and small arteries, renal interstitial fibrosis and tubular atrophy, these could provide the theoretical foundation for early rationalization and Standardized treatment.

关 键 词：肾病 淀粉样变性 病理学特征 相关因素 

分 类 号：R692[医药卫生—泌尿科学]