阿托伐他汀对老年EF值降低型心力衰竭心功能、左室重构和炎症因子的影响  

Effects of Atorvastatin on cardiac function,left ventricular remodeling and inflammatory factors in elderly patients with heart failure of reduced EF

作　　者：黄璟[1] 罗燕华[2] 李国强[1] 熊龙根[1] 

机构地区：[1]广州医科大学附属第二医院心内科,广州心血管疾病研究所,广东广州510260 [2]广州医科大学附属第二医院超声科,广东广州510260

出　　处：《广州医科大学学报》2016年第5期51-53,共3页Academic Journal of Guangzhou Medical University

摘　　要：目的:观察阿托伐他汀对老年EF值降低型心力衰竭(HFr EF)的疗效及对左室重构和炎症因子的影响。方法:将80例老年HFr EF患者随机分为治疗组和对照组,每组40例。两组均给予常规抗心衰治疗,治疗组在此基础上每晚服用阿托伐他汀20 mg,1次/d,疗程均为6个月。测定治疗前、治疗后1、6个月血脂和肿瘤坏死因子-α(TNF-α)水平,并行超声心动图检测左心室射血分数(LVEF)和左心室舒张末期容积指数(LVEDVI)。结果:治疗后两组TNF-α水平均明显降低,治疗1个月时降幅最大,6个月时进一步降低,其中治疗组降幅更明显(P<0.05)。两组LVEF治疗1个月时均明显改善,持续至6个月,其中治疗组改善更明显(P<0.05)。治疗组治疗1个月时LVEDVI出现下降,6个月时降低更为显著,而对照组则在治疗6个月时LVEDVI才明显降低。结论:对于老年HFr EF,在常规抗心衰治疗基础上,加用阿托伐他汀能进一步降低血清TNF-α浓度,改善患者的心功能和心室重构。Objective： To determine the effects of Atorvastatin in elderly patients with heart failure of reduced ejection fraction（ HFr EF）,and its effects on left ventricular remodeling and inflammatory factors.Methods： Eighty elderly patients with HFr EF were randomly divided into the treatment group and the control group（ n = 40 each）. Both groups were given conventional anti-heart failure treatment. In addition,the treatment group was given Atorvastatin 20 mg every night,once/d. The course of treatment was 6 months. The left ventricular ejection fraction（ LVEF） and left ventricular end diastolic volume index（ LVEDVI） were measured by echocardiography before and after treatment. The levels of serum lipids and tumor necrosis factor-α（ TNF-α）were measured at the baseline,and 1 and 6 months after the treatment. Left ventricular ejection fraction（ LVEF）and left ventricular end diastolic volume index（ LVEDVI） were measured by echocardiography. Results： After the treatment,the TNF-α level in the two groups were significantly decreased,and the decrease was the largest at1 month after the treatment. It was further decreased at 6 months after the treatment,and the treatment group decreased more significantly（ P〈0.05）. The LVEF was significant improved at 1 month after the treatment,which was lasted for 6 months in the two groups,and the treatment group was improved more significantly（ P〈0.05）. In the treatment group,LVEDVI was decreased at 1 month after the treatment,and decreased more significantly at 6months after the treatment. In the control group,LVEDVI was decreased significantly at 6 months after the treatment. Conclusion： For elderly patients with HFr EF,using Aatorvastatin on the basis of conventional antiheart failure treatment can further decrease serum TNF-α concentration and improve cardiac function and ventricular remodeling.

关 键 词：心力衰竭 阿托伐他汀 左室重构 TNF-Α 

分 类 号：R541.4[医药卫生—心血管疾病] R541.6[医药卫生—内科学]