氢呼气试验在慢性肾脏病患者胃肠动力评估中的应用  

Application of hydrogen breath test in gastrointestinal motility assessment for patients with chronic kidney diseases

作　　者：张家隆[1] 王永红[1] 张婷[1] 方海东[1] 苏海华[1] 

机构地区：[1]海洋石油总医院肾内科,300452

出　　处：《国际移植与血液净化杂志》2016年第6期17-19,共3页International Journal of Transplantation and Hemopurification

基　　金：天津市滨海新区卫生局重点支持项目（2012BWKJ005）

摘　　要：目的 探讨氢呼气试验（hydrogen breath test,HBT）在慢性肾脏病患者胃肠动力评估中的应用.方法 92例慢性肾脏病（CKD）3b期-4期患者组成CKD组,其中3b期50例,4期42例.45例健康体检者组成对照组.分别应用胃肠电图与HBT对两组人群胃肠动力进行评估,其中胃肠电图测量平均频率（AF）、波形主功率（DP）、波形平均幅值（vpp）,HBT测量口-结肠转运时间（oral-colon transit time,OCTT）并进行比较.结果 单因素相关分析显示,摄入乳果糖前后CKD组、对照组0CTT与AF、DP、Vpp呈明显负性相关,差异有统计学意义（P〈0.05）.两种方法对胃肠排空延迟、排空正常、排空过速的检出率无显著差别（P〉0.05）.CKD组胃肠排空延迟、胃排空过快患者均较对照组明显升高（P〈0.05）.结论 CKD组患者普遍存在胃肠功能紊乱.氢呼气试验测定口-结肠转运时间可以作为评估慢性肾脏病患者胃肠动力简便、可靠、安全、可行的方法.Objective To investigate the application of hydrogen breath test in gastrointestinal motility assessment of patients with chronic kidney diseases.Methods A total of 92 patients with chronic kidney diseases（CKD） of 3b to 4 stage were selected（CKD group）.45 health check-up individuals were selected （control group）.Average frequency （AF）,main power （DP）,average amplitude of waveform （Vpp） and OCTT were tested for two groups.Results Compared with EGEG,there was no significant difference in the positive of delayed gastric emptying,nornal gastric emptying or gastric emptying too fast for HBT（P 〉 0.05）.Before or after uptaking lactulose,OCTT was negatively correlated with AF,DP,Vpp in two groups.Conclusions HBT is a simple,reliable,safe and feasible methond for gastrointestinal motility of patients with diabetic nephropathy.

关 键 词：氢呼气试验 胃肠电图 慢性肾脏病 胃肠动力 

分 类 号：R692[医药卫生—泌尿科学]