扶正抗癌方联合化疗治疗肝胃不和型胃癌效应观察  

Clinical Effect and Mechanism of of Healthy qi Reinforcing and Anti-cancer Decoction in Treatment of Stomach Cancer with Liver-stomach disharmony syndrome

作　　者：王小龙[1] 徐彬[1] 周雷[1] 马俊杰[1,2] 李智强[1] 徐增柏 

机构地区：[1]南京中医药大学教学医院,江苏省沭阳县中医院肿瘤科,宿迁223600 [2]南京中医药大学基础医学院,南京210046

出　　处：《世界中医药》2016年第8期1457-1460,共4页World Chinese Medicine

基　　金：宿迁市科技项目--扶正抗癌方治疗肝胃不和型胃癌临床疗效及机制研究(编号:Z201517)

摘　　要：目的:观察扶正抗癌方联合西药治疗肝胃不和型胃癌的疗效及机制。方法:将41例胃癌患者随机分为治疗组和对照组,均给予多西他赛40 mg/m^2,第1,8天,静脉滴注1 h,并常规给予抗过敏预处理;奥沙利铂75 mg/m^2,第1天,静脉滴注2 h;21 d为1个周期,共化疗2个周期。对照组21例在此基础上加服安慰剂;治疗组20例在上述治疗的基础上加用扶正抗癌方,治疗1个疗程(40 d)。疗程结束后,判定疗效,观测临床症状、症状积分、不良反应及免疫指标等。结果:治疗组治疗总有效率显著高于对照组(P<0.05),免疫功能相关指标优于对照组(P<0.05),KPS评分(卡氏生活质量评分)显著优于对照组(P<0.05)。结论:扶正抗癌方联合西药治疗肝胃不和型胃癌疗效满意,无严重不良反应,可显著改善免疫功能及生存状况,值得推广应用。Objective：To explore the clinical curative effect and mechanism of Healthy qi Reinforcing and Anti-cancer Decoction in the treatment of stomach cancer in liver-stomach disharmony syndrome.Methods：Total 41 cases of patients with stomach cancer were randomly divided into treatment group and control group,both groups were given intravenous drip Docetaxel with 40 mg / m^2 for 1 hour at 1 st and 8th days＇ treatment,with an allergy conventional pretreatment;Oxaliplatin 75 mg / m^2,intravenous drip for 2hour at the first day;the chemotherapy lasted for 2 session,each session lasted for 21 d.The 21 cases in the control group received placebo on the base of the treatment;The 20 cases in treatment group also received Healthy qi Reinforcing and Anti-cancer Decoction for 1 session（ 40 d）.The curative effect,clinical symptoms,symptom integral,adverse reactions,and immune index were observed.Results：The total effective rate of the observation group was significantly higher than control group（ P〈0.05）,the related parameters of immune function were better than control group（ P〈0.05）,KPS score（ carr＇s quality of life score） was significantly better than control group（ P〈0.05）.Conclusion：The results of the Healthy qi Reinforcing and Anti-cancer Decoction combined western medicine therapy is satisfied in the treatment of stomach cancer with liver-stomach disharmony syndrome,with no serious adverse reactions,and can significantly improve the immune function and survival condition,which is worthy of popularization and application.

关 键 词：扶正抗癌方 中医药 化疗 肝胃不和 胃癌 

分 类 号：R273[医药卫生—中西医结合] R289.5[医药卫生—中医肿瘤科]