补肾填精益髓方对慢性再生障碍性贫血出血及感染的影响  

Effect of Bushen Tianjing Yisui Decoction on Bleeding and Infection in Treating Patients with Chronic Aplastic Anemia

作　　者：吴玉霞[1] 袁忠[2] 马西虎[1] 黄志惠[1] 费飞[1] 

机构地区：[1]新疆医科大学附属中医医院血液科,乌鲁木齐830011 [2]新疆医科大学附属中医医院肾病科,乌鲁木齐830011

出　　处：《世界中医药》2016年第8期1497-1499,1503,共4页World Chinese Medicine

基　　金：2010-2011年中医药行业科研专项(编号:201107001)--"慢性再生障碍性贫血致重因素中医干预方案的研究"

摘　　要：目的:观察从补肾填精益髓法对慢性再生障碍性贫血(Chronic Aplastic Anemia,CAA)出血及感染的影响。方法:符合入选病例标准的CAA门诊及住院患者56例,据辨证首先予以分层,分层原则是依据肾阳虚、肾阴虚、阴阳两虚发病率,比例选择2∶2∶1。下一步进入随机分组。随机分为2组,在支持疗法相同的情况下,治疗组给予依据辨证分型的受试药物,对照组施以受试药完全一致的模拟剂。每组疗程均为6个月。比较2组及治疗组3型治疗后中医证候疗效及血象、出血与感染次数等相关指标的变化。结果:1)中医证候疗效比较:治疗组及对照组总有效率分别为71.42%(20/28)、30.71%(6/28),2组比较差异有统计学意义(P<0、05);治疗组中肾阳虚型有效率优于其他证型,差异有统计学意义(P<0.05);2)外周血象比较:治疗组各项指标均有改善,与治疗前比差异有统计学意义(P<0.05),治疗组中肾阳虚型各项指标改善优于其他证型,差异有统计学意义(P<0.05);3)出血及感染情况(次数)比较:治疗组与治疗前比较差异有统计学意义(P<0.05),与对照组治疗后比较差异有统计学意义(P<0.05),治疗组中肾阳虚型组低于其他证型组,差异有统计学意义(P<0.05)。结论:补肾填精益髓中药能明显提高中医证候疗效,提高血细胞水平,减轻出血及感染的发生避免慢性再障疾病进一步加重,对慢再障的缓解率和生活质量提高均有很好的作用。Objective：To observe the effect of Bushen Tianjing Yisui Decoction（ BTYD） on bleeding and infection in treating patients with chronic aplastic anemia（ CAA）.Methods：Fifty-six patients with CAA were randomly divided into two groups.Twenty-eight patients in the treatment group were divided into 3 pattern types,namely kidney-yang-deficiency,kidney-yin-deficiency and kidney-yin yang-deficiency（ with the radio of 2：2：1） and were orally administered with BTYD in accordance with their patterns.The rest 28 patients were administered with same traditional Chinese medicine simulation agent in the control group.The therapeutic course was 6 months.Peripheral blood cells and the frequency of bleeding and infection before and after treatment were observed and TCM patterns clinical efficacy of the treatment was evaluated.Results：（ 1） Comparison in TCM patterns：The effect rate of in the treatment group was 71.42%（ 20 /28） and 30.71%（ 6 /28） in the control group,respectively,showing a significant difference between the two groups（ P〈0.05）.The improvement of the kidney-yang-deficiency group in treatment groups were superior to that of the other patterns group（ P〈0.05）.（ 2） Comparison in peripheral blood：The improvement of peripheral blood in the treatment group were superior to those in the control group（ P〈0.05）.The kidney-yang-deficiency group in treatment groups were superior to the other patterns group（ P〈0.05）.（ 3） The frequency of bleeding and infection in the treatment group were lower than that in the control group（ P〈0.05）.The kidney-yang-deficiency group in treatment groups were lower than the other patterns groups（ P〈0.05）.Conclusion：Bushen Tianjing Yisui Decoction（ BTYD） on CAA may degrade the frequency of bleeding and infection and also improve remission rate of CCA and quality of life.

关 键 词：补肾填精益髓方 慢性再生障碍性贫血 出血及感染 

分 类 号：R259[医药卫生—中西医结合]