丹参注射液体外对格列喹酮血浆蛋白结合率的影响  

In Vitro Effect of Salvia miltiorrhiza Injection on Plasma Protein Binding Rate of Gliquidone

作　　者：张瑞[1] 杨晔[1] 王炜[1] 倪妮[1] 尹登科[1,2] ZHANG Rui YANG Ye WANG Wei NI Ni YIN Deng-ke(School of Pharmacy, Anhui University of Chinese Medicine, Anhui Hefei 230012, China In stitute of Pharmaceutics, Anhui Academy of Chinese Medicine, Anhui Hefei 230012, China)

机构地区：[1]安徽中医药大学药学院,安徽合肥230012 [2]安徽省中医药科学院药物制剂研究所,安徽合肥230012

出　　处：《安徽中医药大学学报》2017年第2期72-76,共5页Journal of Anhui University of Chinese Medicine

基　　金：国家自然科学基金项目(81102682);安徽省高等学校自然科学基金项目(KJ2015A130)

摘　　要：目的考察丹参注射液体外对格列喹酮血浆蛋白结合率的影响。方法采用平衡透析法和高效液相色谱法,分别在有无丹参注射液的情况下对格列喹酮血浆蛋白结合率进行测定。结果格列喹酮高浓度(12.6μg/mL)、中浓度(6.3μg/mL)、低浓度(1.26μg/mL)的血浆蛋白结合率差异无统计学意义(P>0.05)。在含有高浓度(750mg/mL)、中浓度(375 mg/mL)、低浓度(75 mg/mL)丹参注射液时,格列喹酮(12.6μg/mL)的血浆蛋白结合率分别为(82.6±3.11)%、(87.3±9.80)%、(92.6±4.21)%。在含有高浓度丹参注射液时,格列喹酮血浆蛋白结合率显著降低(P<0.05)。结论在临床剂量下,丹参注射剂不会影响格列喹酮血浆蛋白结合率。Objective To investigate the in vitro effect of Salvia miltiorrhiza injection on the plasma pro tein binding rate of gliquidone. Methods Equilibrium dialysis and high-performance liquid chromatogra- phy were used to measure the plasma protein binding rate of gliquidone with the presence or absence of Salvia miltiorrhiza injection. Results There were no significant differences in plasma protein binding rate between high, medium, and low concentrations of gliquidone （12.6, 6.3, and 1.26μg/mL, respectively） （P〈0.05）. With the presence of the high-, medium-, and low-concentration Salvia miltiorrhiza injections （750, 375, and 75 mg/mL, respectively）, the plasma protein binding rates of gliquidone were （82.6±3.11）, （87.3±9.80） %, and （92.6±4.21） %, respectively. With the presence of high-concentra- tion Salvia miltiorrhiza injection, there was a significant reduction in the plasma protein binding rate of gliquidone （P〈0.05）. Conclusion Salvia miltiorrhiza injection at the dose used in clinical practice does not affect the plasma protein binding rate of gliquidone.

关 键 词：格列喹酮 丹参注射液 平衡透析法 血浆蛋白结合率 

分 类 号：R285.5[医药卫生—中药学]