脑血管疾病与阿尔茨海默病的联系及其机制  

Connection and Mechanism Between Cerebrovascular Disease and Alzheimer's Disease

作　　者：王国佐[1] 龚盛强 尹芳[1] 王珊珊[1] 易压乔 成绍武[1] 

机构地区：[1]湖南中医药大学中西医结合学院,长沙410208 [2]湖南中医药大学中医学院,长沙410208

出　　处：《世界中医药》2016年第9期1897-1900,共4页World Chinese Medicine

基　　金：国家自然科学基金青年项目(编号:81202794)--"特异性蛋白质相互作用网络在脑梗死发生中的作用及中药脑泰方干预机制研究"

摘　　要：脑血管疾病和阿尔茨海默病(AD)之间存在很大程度的交叉重叠(如共同的危险因素和某些相同的病理变化),提示它们可能在影响认知功能下降方面具有相加或协同作用。脑老化和AD最常见的血管病变是脑淀粉样血管病变和小血管病变,高达84%的老年AD患者显示不同程度的脑血管疾病的病理改变。虽然目前不能确定脑血管病变是影响AD的发生还是发展,但是它确实在AD的神经元功能紊乱中起重要作用。进一步阐明脑血管疾病和AD影响认知功能下降的机制对于全面理解AD神经退变的发生和发展有着重要的意义,将为AD的预防和治疗提供新的思路。Epidemiological and clinico-pathological data indicate that there is considerable overlap between Cerebrovascular disease（ CVD） and Alzheimer＇s disease（ AD） and suggest that there are additive or synergistic effects of both pathologies on cognitive decline. The most frequent vascular pathologies in the aging brain and in AD are cerebral amyloid angiopathy and small vessel disease. Up to 84% of aged subjects show morphological substrates of CVD in addition to AD pathology. Although the effects of CVD on the development and progression of dementia are unclear,it has been well confirmed that CVD contributes to the neurodegeneration of AD. Further study of the relationship between CVD and AD will allow us to fully understand the mechanism of the development and progression of dementia and lead to the discovery of other novel therapeutic targets for AD.

关 键 词：阿尔茨海默病 脑血管疾病 脑淀粉样血管病 认知损害 

分 类 号：R259[医药卫生—中西医结合]