复方二至天癸颗粒对IVF准备周期子宫内膜Galectin-3的影响研究  

Effect of Erzhi Tiangui Granules on the IVF Cycle Endometrial Galectin-3

作　　者：张君探[1] 连方[2] 赵地[3] 

机构地区：[1]枣庄市妇幼保健院生殖医学中心,枣庄277000 [2]山东中医药大学附属医院,济南250011 [3]山东中医药大学,济南250011

出　　处：《世界中医药》2016年第10期1970-1973,1977,共5页World Chinese Medicine

基　　金：国家自然科学基金项目--基于体外受精-胚胎移植卵巢颗粒细胞基因组学的肾主生殖理论研究(编号:81273790);国家自然科学基金项目--基于蛋白质组学的肾主生殖理论研究(编号:81072836);国家自然科学基金项目--基于关键基因表达调控网络的肾主生殖理论研究(编号:81473720)

摘　　要：目的:观察复方二至天癸颗粒对体外受精-胚胎移植(IVF-ET)准备周期子宫内膜半乳糖凝集素-3(Galectin-3)表达的影响,从而改善子宫内膜容受性,提高妊娠率的可能机制。方法:按随机数字表法将进入体外受精-胚胎移植(IVF-ET)准备周期的不孕患者分为2组,治疗组31例,对照组31例,分别予复方二至天癸颗粒、复方六味地黄颗粒预处理2个周期,并在第二周期月经第21天,吸取内膜组织少许,检测Galectin-3;同时分别对2组患者肾气阴两虚证候积分变化、临床妊娠率进行评定。结果:2组患者肾虚症候均有改善,治疗组改善更加明显(P<O.05);2组子宫内膜Galectin-3表达比较,治疗组大于对照组(P<O.05);临床妊娠率比较,治疗组大于对照组(P<0.05)。结论:复方二至天癸颗粒提高IVF周期患者临床妊娠率,可能与提高Galectin-3在子宫内膜中的表达,抑制子宫内膜免疫及改善其容受性有关。Objective： Observe the effect of Erzhi Tiangui granule on IVF-ET（IVF-ET） in preparing the endometrium period galectin-3（Galectin-3）,and its mechanism in improving the endometrial receptivity and increasing the possibility of pregnancy.Methods： Patients in vitro fertilization-embryo transfer（IVF-ET） preparation cycle were randomly divided into two groups,with 31 cases in the treatment group and 31 patients in the control group. The control group was given Liuwei Dihuang pills for cycles,and the treatment group was given Erzhi Tiangui granules for the same period. On the second cycle of menstruation,the 21 st day,extract a small amount of endometrial for detection of Galectin-3. At the same time,evaluate the kidney qi deficiency score and conceive rate of the two groups. Results： Kidney deficiency in both groups of patients were improved and treatment group more significantly（P 〈0. 05）. Galectin-3 expression in the treatment group also improved more obvious than that of the control group（P 〈0. 05）. As to clinical pregnancy rate,the treatment group performed better than the control group（P 〈0. 05）. Conclusion： Erzhi Tian Gui granules can improve patient＇s clinical pregnancy rate in IVF cycle. This may relate to its enhancement of the expression of Galectin-3 in the endometrium and endometrial immune suppression.

关 键 词：GALECTIN-3 补肾 复方二至天癸颗粒 子宫内膜容受性 免疫 

分 类 号：R242[医药卫生—中医临床基础] Q132.1[医药卫生—中医学]