参苓胃消胶囊对乳腺癌化疗期患者外周血中炎性反应因子水平及消化道反应的影响分析  

Effect of Ginseng and Poria Stomach Capsule on Gastrointestinal Reaction and Inflammatory Factor Levels of Peripheral Blood in Patients with Breast Cancer in Chemotherapy Period

作　　者：骆瑞珍[1] 张超[1] 王庆海[1] 陈秀霞[1] 

机构地区：[1]河北省沧州中西医结合医院乳腺外科,沧州061001

出　　处：《世界中医药》2016年第11期2336-2339,共4页World Chinese Medicine

基　　金：河北省中医药管理局科研计划项目(编号:2011156)

摘　　要：目的:探讨参苓胃消胶囊对乳腺癌化疗期患者外周血中炎性反应因子水平及消化道反应的影响。方法:选取2011年6月至2015年7月期间我院确诊治疗的乳腺癌化疗期患者128例,依据随机分配原则分为观察组和对照组,每组64例,对照组患者在化疗期间给予阿扎司琼治疗(10 mg/次,1次/d,静脉输注至化疗后第7天),观察组患者给予参苓胃消胶囊治疗(2粒/次,3次/d,口服至化疗后第7天),采用酶联免疫吸附法检测所有患者治疗前后外周血中C-反应蛋白(Creactive protein,CRP)、肿瘤坏死因子-α(Tumor necrosis Factor-α,TNF-α)、白细胞介素6(Interleukin-6,IL-6)水平,统计分析所有患者治疗疗效、治疗前后外周血中炎性反应因子水平及其消化道反应。结果:观察组患者治疗有效率明显高于对照组,差异有统计学意义(P<0.05);观察组患者治疗后外周血中CRP、TNF-α、IL-6水平明显低于对照组,差异有统计学意义(P<0.05);观察组患者消化道不良反应发生率明显低于对照组,差异有统计学意义(P<0.05)。结论:参苓胃消胶囊可有效减少乳腺癌化疗期患者消化道不良反应的发生,减轻机体炎性反应,提高患者的耐受能力,有利于顺利完成化疗并提高疗效,值得临床作进一步推广。Objective：To discuss the effect of Ginseng and Poria Stomach Capsule on gastrointestinal reaction and inflammatory factor levels of peripheral blood in patients with breast cancer in chemotherapy period .Methods：A total of 132 patients with breast cancer were selected and divided randomly into capsule group and control group ,66 in each group .The control group patients re-ceived Azasetron（10 mg/time,1 /d,intravenous infusion given for 7 days after chemotherapy ）,capsule group patients received Ginseng and Poria Stomach Capsule （2 pills /time,3 times/d,to oral taken for 7 days after chemotherapy ）.The enzyme-linked im-munosorbent method was used to detect the C-reactive protein（CRP）,tumor necrosis factor-α（TNF-α）,interleukin 6（IL-6）level of peripheral blood of all patients after the treatment .Results：Curative effect of the capsule group was significantly higher than the control group（P〈0.05）;After treatment,the peripheral blood CRP ,TNF alpha,IL-6 levels of the capsule group were significantly lower than the control group （ P〈0.05）;The gastrointestinal adverse reactions of the capsule group were significantly lower than the control group（P〈0.05）.Conclusion：Ginseng and Poria Stomach Capsule can effectively reduce the gastrointestinal adverse reaction of breast cancer patients in chemotherapy period ,and reduce the body′s inflammatory response ,improve the patient′s toler-ance,which is conducive to the smooth completion of chemotherapy and improvement of the curative effect .

关 键 词：参苓胃消胶囊 乳腺癌 疗效 炎性反应 消化道反应 

分 类 号：R273[医药卫生—中西医结合]